Fasting Mimicking Diet and Autophagy Study
exploratorybiomarker · high · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Evaluate whether fasting mimicking diet exposure modulates autophagy and metabolic health markers in generally healthy human volunteers.
Pilot randomized clinical trial comparing ProLon, FMD2, and control over an 8-day protocol; autophagic flux measured in peripheral blood mononuclear cells using LC3B-II/LC3B-I response to chloroquine ex vivo, with metabolic markers including glucose, insulin, IGF-1, beta-hydroxybutyrate, and HOMA-IR.
A 2025 GeroScience publication reported results from the L-Nutra-sponsored trial registered as NCT06115551.
Significant between-group differences were observed from baseline to the end of the 6-day dietary intervention for body weight, fasting glucose, beta-hydroxybutyrate, HOMA-IR, and autophagic flux, although differences were not significant across all time points.
L-Nutra Health Metabolic Health Program
exploratoryresearch program · high · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Apply fasting mimicking diet technology to metabolic health conditions including obesity and type 2 diabetes, with a focus on improving glycaemic control and reducing medication burden.
Periodic 5-day FMD cycles integrated with usual or primary care for people with type 2 diabetes; health-economic modeling of a 3-year FMD program added to standard diabetes care.
A 2025 cost-utility analysis modeled 10-year outcomes for adding a 3-year FMD program to diabetes standard care in the United States.
The 2024 randomized trial reported reduced glucose-lowering medication need, improved HbA1c despite medication reduction, improved glycaemic management in 53% of FMD participants versus 8% of controls, and lower body weight. The 2025 model projected 11.4% fewer diabetes complications, 67.2% less overall diabetes medication use, 45.0% fewer hypoglycemia events, 0.211 additional QALYs, and cost savings.
ProLon Fasting Mimicking Diet
approvedconsumer product · high · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Provide a plant-based 5-day fasting mimicking diet program intended to support healthspan, longevity, metabolic health, cellular rejuvenation, and fasting-related physiologic effects.
Commercial 5-day plant-based dietary program consumed periodically to mimic fasting while providing formulated nutrition.
L-Nutra offers Prolon as a 5-day Fasting Mimicking Diet program; multiple clinical studies evaluate FMD cycles in humans.
Clinical publications report improvements in metabolic markers, glycaemic management, medication use, body weight, skin hydration, skin texture maintenance, and autophagic flux markers, depending on study population and protocol.
Fasting Mimicking Diet Skin Health Program
exploratoryresearch program · high · Sun Jan 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time)
Assess whether monthly 5-day FMD cycles can improve facial skin appearance, skin hydration, skin texture, and related self-reported psychological well-being measures.
Single-center randomized controlled clinical trial of a sponsor 5-day meal kit consumed monthly for 3 cycles over 71 days in women with mild to moderate dry fine lines, lack of smoothness, uneven skin tone, and lack of radiance.
A 2023 randomized controlled trial publication reported skin hydration, skin roughness, and self-reported outcome results.
Three monthly FMD cycles significantly increased skin hydration at day 11 and day 71 relative to baseline, maintained skin texture compared with increased roughness in controls, and improved self-reported happiness and confidence components.
Fasting Mimicking Diet in Chemotherapy of Gynecologic Malignancies
exploratoryresearch program · medium · Wed Sep 08 2021 00:00:00 GMT+0000 (Coordinated Universal Time)
Evaluate whether fasting mimicking diet or related lifestyle modifications may help manage chemotherapy side effects in patients with gynecologic malignancies.
Clinical study evaluating lifestyle modifications in patients receiving chemotherapy for gynecologic malignancies.
ClinicalTrials.gov record NCT06376604 was published on 2021-09-08.
Fast Bar
exploratoryconsumer product · medium · Mon Mar 01 2021 00:00:00 GMT+0000 (Coordinated Universal Time)
Support or extend physiological fasting and ketosis during intermittent fasting or time-restricted eating using a specially formulated low-calorie nutrition bar.
Randomized controlled studies assessing a specially formulated Fast Bar consumed after overnight fasting, with coffee or tea, at night, or during fasting protocols; physiological fasting parameters and ketosis are measured.
ClinicalTrials.gov records describe Fast Bar studies, and a publication reports that a 200-calorie fasting-mimicking nutrition bar extends physiologic ketosis in time-restricted eating.
The supplied publication title states that an intermittent fasting mimicking nutrition bar extends physiologic ketosis in time restricted eating; detailed outcome values are not available in the supplied excerpt.
