Cribriform plate CSF egress diagnostic research
exploratoryEvaluate whether cribriform plate aging or pathology and impaired CSF egress are associated with cognitive impairment and Alzheimer's disease risk.
Human cribriform plate morphology assessment using CT and deep learning, memory testing, olfactory discrimination testing, post-mortem micro-CT analysis, and ferret model experiments.
A medRxiv study reported post-mortem analysis of 70 samples, a ferret model, and a clinical study with 560 volunteers.
The supplied abstract reports that cribriform plate aperture cross-sectional area limits CSF flux, declines with age, was smallest in subjects with confirmed Alzheimer's disease, and that deep learning algorithms showed feasibility for predicting Alzheimer's disease years before clinical cognitive impairment.