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thymus regeneration, immune monitoring, epigenetic clocks
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C-N1UJC-N1UJthymus regeneration, immune monitoring, epigenetic clocks
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Reversal of Immunological, Epigenetic, and Physiological Aging Trends in Humans. Dr. Greg Fahy (Intervene Immune)
Quick Pitch: Bobby Brooke, MS Intervene Immune
📝 Sign up for our newsletter for the latest tips and insights! https://www.drkarafitzgerald.com/newsletter/ 🧬 Curious about your biological age? Take our Bio Age Quiz now! https://drkarafitzgerald.outgrow.us/drkarafitzgerald-6 Your thymus isn't talked about much, but this small organ in your upper chest is a key component of your immune system that is solely responsible for the essential "education" of the immune cells that protect your body from invaders. Through this action it also affects levels of inflammation (an immune-mediated process). It's also interesting to note that most of us end up dying of an immune-related dysfunction - even cardiovascular disease, as Dr. Greg Fahy points out in this New Frontiers podcast, is often caused by atherosclerosis driven by underlying chronic inflammation. I was thrilled to finally sit down with Dr. Fahy, whose groundbreaking work in aging has truly reshaped our understanding of what’s possible. His 2019 TRIIM study, showing clear epige
Greg Fahy, Co-founder and CSO of Intervene Immune presenting at the Rejuvenation Startup Summit 2024 Connect to Forever Healthy: * Videos: https://forever-healthy.org/videos/ * News: https://forever-healthy.org/news/ * LinkedIn: https://www.linkedin.com/company/forever-healthy-foundation
Dr Greg Fahy co-founder of Intervene Immune talks about the plan to make the TRIIM-X therapy for rejuvenating the thymus available in clinics. Watch the complete video for background on what TRIIM-X will provide. Some links are affiliate links so we will earn a commission when they are used to purchase products. NOVOS Labs $5 discount Code 5OFFMHS24 NOVOS Core https://novos.sjv.io/AWv6QN, Vital https://novos.sjv.io/vNJd6y Renue By Science 10% : Code MHS NMN https://tinyurl.com/3wr8pr3t Quercetin https://tinyurl.com/22huycrz DoNotAge 10% discount code MHS https://tinyurl.com/6dbvhv87 D3/K2 https://tinyurl.com/528z26b7, Omega-3 https://tinyurl.com/2h79stt2 Bulletproof 15% off with coupon code: HEALTHSPAN15: https://tinyurl.com/4npjk5vp Inner Fuel Gut support https://bulletproof.fdf2.net/PyDKDM Omega-3 Krill Oil https://bulletproof.fdf2.net/xkdxmy Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN Neurohacker Quali
Dr Greg Fahy co-founder of Intervene Immune talks about the key results from TRIIM-XA, 1. rejuvenated immune system, 2, improved physical fitness both strength and VO2max, and improved body composition. Some links are affiliate links so we will earn a commission when they are used to purchase products. NOVOS Labs $5 discount Code 5OFFMHS24 NOVOS Core https://novos.sjv.io/AWv6QN, Vital https://novos.sjv.io/vNJd6y Renue By Science 10% : Code MHS NMN https://tinyurl.com/3wr8pr3t Quercetin https://tinyurl.com/22huycrz DoNotAge 10% discount code MHS https://tinyurl.com/6dbvhv87 D3/K2 https://tinyurl.com/528z26b7, Omega-3 https://tinyurl.com/2h79stt2 Bulletproof 15% off with coupon code: HEALTHSPAN15: https://tinyurl.com/4npjk5vp Inner Fuel Gut support https://bulletproof.fdf2.net/PyDKDM Omega-3 Krill Oil https://bulletproof.fdf2.net/xkdxmy Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN Neurohacker Qualia Senolytic
BiOptimizers Magnesium Breakthrough 10% with code Modern10 https://bioptimizers.com/modern. This video brought to you by BiOptimizers. Dr Greg Fahy co-founder of Intervene Immune gives us an update on the TRIIM-X trial and the steps towards bringing the TRIIM therapy to the clinic. Some links are affiliate links so we will earn a commission when they are used to purchase products. NOVOS Labs $5 discount Code 5OFFMHS24 NOVOS Core https://novos.sjv.io/AWv6QN, Vital https://novos.sjv.io/vNJd6y Renue By Science 10% : Code MHS NMN https://tinyurl.com/3wr8pr3t Quercetin https://tinyurl.com/22huycrz DoNotAge 10% discount code MHS https://tinyurl.com/6dbvhv87 D3/K2 https://tinyurl.com/528z26b7, Omega-3 https://tinyurl.com/2h79stt2 Bulletproof 15% off with coupon code: HEALTHSPAN15: https://tinyurl.com/4npjk5vp Inner Fuel Gut support https://bulletproof.fdf2.net/PyDKDM Omega-3 Krill Oil https://bulletproof.fdf2.net/xkdxmy Nuchido Time+ 20% discount of first purc
Dreams & Sleep for Restore Health, & Disease Reversal with Dr. Joseph Scherger Description- Sleep and dreams are essential to our restorative healing and remission. How important is it for our healthy life? Dr. Joseph Scherger is here to tell us. According to current research and testimonials from patients, including myself, you can reverse most of your chronic diseases and stop most of your medications. Tonight, our guest, Dr. Joseph Scherger, will explain how to do this and share the latest in anti-aging strategies so that your healthy lifespan may reach the boundaries of what is possible. BIO: Joseph E. Scherger, M.D., M.P.H. is founder and Medical Director of Restore Health - Disease Reversal. He is also a core faculty member with the Eisenhower Health Family Medicine Residency Program. Dr. Scherger is Clinical Professor of Family Medicine at USC, UC Riverside and Loma Linda, author of Lean and Fit: A Doctor's Journey To Healthy Nutrition and Greater Wellness (Third Editi
On part 2 of the Healthy Aging Series, our host Rick Jentis speaks with Bobby Brooke, Executive Director of The Clock Foundation and CEO & CTO of Intervene Immune. He asks the burning question of why people age differently and why we may feel a different age than we are chronologically. Their discussion will help us understand the difference between our biological clocks and our chronological clocks and how they affect the way we age, also further diving into the biomarkers of aging and how our immune system plays a role. Bobby Brooke provides insight into his interesting research on epigenetic clocks and how they are being used to help predict future illness to increase the chances of living a long and healthy life. This podcast is hosted by Nestlé Health Science. This podcast represents the opinions of host Rick and his guest on the show and does not reflect the opinion of Nestlé Health Science. The content is for informational purposes only and should not be taken as medical ad
*This video was recorded at Foresight's Longevity Frontiers Workshop 2023.* https://foresight.org/longevity-frontiers-workshop-2023/ Many longevity areas are still underexplored. Some were surfaced by our 2022 workshop, some are highlighted by the Longevity Prize, some are entirely new. This two-day event invites leading researchers, entrepreneurs, and funders to drive progress. Explore new opportunities, form lasting collaborations, and join us in driving cooperation toward shared long-term goals.Rapid keynotes are followed by working groups to curate opportunities for talent and funders, present at the workshop and beyond, to take on. Including mentorship hours, breakouts, and speaker & sponsor gathering. *Foresight Biotech & Health Extension program & apply to join:* https://foresight.org/biotech-health-extension-program/ A group of scientists, entrepreneurs, funders, and institutional allies who cooperate to advance biotechnology to reverse aging and extend human healthspan. This
Dr. Greg Fahy gives an update on the TRIIM-X clinical trial at EARD 2022. The TRIIM-X clinical trial aims to understand how to create a personalized thymus regeneration regimen. By regenerating the thymus, the researchers hope to be able to prevent or reverse certain aspects of immune system aging. FOLLOW US ▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀ https://www.lifespan.io https://www.facebook.com/lifespanio https://www.instagram.com/lifespan.io/ DESCRIPTION ▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀ Dr. Fahy holds a Bachelor of Science degree in Biology from the University of California at Irvine and a Ph.D. from the Medical College of Georgia in Augusta. Dr. Fahy used to be the Head of the Tissue Cryopreservation Section of the Transfusion and Cryopreservation Research Program for the U.S. Naval Medical Research Institute in Bethesda, Maryland, where he developed the original concept of ice blocking agents. Dr. Fahy is the Chief Scientific Officer and co-founder of Intervene Immune, a biotech company researc
“Every cell in your body still remembers how to be young. By adjusting gene expression in that cell, all you have to do is remind it.” The Everything Else Show: Gregory M. Fahy, PhD and Paul Hynek join us, Paul was in the first medically verifiable trial making people younger. How does it work? Is it possible for us to prevent the breakdown of our physical bodies? Is it even the right thing to do? Paul Hynek’s personal lifespan was increased by 10 years after participating in the groundbreaking TRIIM trial and a subsequent additional program. The TRIIM trial was the first ever approved by the FDA that wasn't to combat a specific disease but rather aging as a whole. This was the first time in history that someone was tested by Steve Horvath’s epigenetic clock test and actually tested younger than they previously had. The results were published in Sept. 2019 in Aging Cell magazine. Check out: http://interveneimmune.com/interveneimmune.com/ https://www.weareageist.com/uncategorized/p
#NFTsLongevitySpace: Funding #LongevityResearch w/ NFT’s Proceeds. Colorblind watercolor artist Adam Stewart shares with us how he came to conceive his #2Tulips series of three #NFTs: • 2Tulips: Proof of Work • 2Tulips: Proof of Storage • 2Tulips: Proof of Burn. About #NFTsLongevityProjects Episode One. Originally live-streamed via Twitter Spaces with host Tonya Scholz and co-hosts Brian & Adam Stewart. This episode was originally live-streamed Saturday, November 13 @ 6 PM PST | 9 PM EST chat w/ Dr. Fahy & Bobby Brooke from Intervene Immune. ( http://interveneimmune.com) about their longevity research on thymus regeneration and immune monitoring program. Adam donates proceeds Auction 2Tulips: Proof of Burn NFT to it. It is part of the 2Tulips series of three NFTs: • 2Tulips: Proof of Work • 2Tulips: Proof of Storage • 2Tulips: Proof of Burn. https://opensea.io/assets/0xf36e6bd9c... All proceeds of this NFT will be donated to Greg Fahy, a longevity researcher who has demonstrated human
Brian chat with Bobby Brooke, Co-Founder of Intervene Immune, dedicated to reversing a process called "thymic involution" in people about the TRIIM trials results. Background: Tonya Scholz host a #NFTsLongevityProjects Twitter Spaces w/ co-hosts Brian & Adam Stewart originally live-streamed Saturday, November 13 @ 6 PM PST | 9 PM EST chat w/ Dr. Fahy & Bobby Brooke from Intervene Immune. ( http://interveneimmune.com) about their longevity research on thymus regeneration and immune monitoring program. Adam donates proceeds Auction 2Tulips: Proof of Burn NFT to it. This is part of the 2Tulips series of three NFTs: • 2Tulips: Proof of Work • 2Tulips: Proof of Storage • 2Tulips: Proof of Burn. https://opensea.io/assets/0xf36e6bd9c... All proceeds of this NFT will be donated to Greg Fahy, a longevity researcher who has demonstrated human rejuvenation via thymus regeneration. This video documents the process of burning 2Tulips. Tulips are special to Adam, and their historical signifi
Robert (Bobby) Brooke, CEO & CTO, Co-founder Intervene Immune, shared his thought on why he and Dr. Greg Fahy joined forces to launch Intervene Immune. About #NFTsLongevityProjects Episode One. Originally live-streamed via Twitter Spaces with host Tonya Scholz and co-hosts Brian & Adam Stewart. This episode was originally live-streamed Saturday, November 13 @ 6 PM PST | 9 PM EST chat w/ Dr. Fahy & Bobby Brooke from Intervene Immune. ( http://interveneimmune.com) about their longevity research on thymus regeneration and immune monitoring program. Adam donates proceeds Auction 2Tulips: Proof of Burn NFT to it. This is part of the 2Tulips series of three NFTs: • 2Tulips: Proof of Work • 2Tulips: Proof of Storage • 2Tulips: Proof of Burn. https://opensea.io/assets/0xf36e6bd9c... All proceeds of this NFT will be donated to Greg Fahy, a longevity researcher who has demonstrated human rejuvenation via thymus regeneration. This video documents the process of burning 2Tulips. Tulips ar
Tonya Scholz host a #NFTsLongevityProjects Twitter Spaces w/ co-hosts Brian & Adam Stewart originally live-streamed Saturday, November 13 @ 6 PM PST | 9 PM EST chat w/ Dr. Fahy & Bobby Brooke from Intervene Immune. ( http://interveneimmune.com) about their longevity research on thymus regeneration and immune monitoring program. Adam donates proceeds Auction 2Tulips: Proof of Burn NFT to it. This is part of the 2Tulips series of three NFTs: • 2Tulips: Proof of Work • 2Tulips: Proof of Storage • 2Tulips: Proof of Burn. https://opensea.io/assets/0xf36e6bd9cbe8d1cfbfb31dacf15784738cc8e8ac/4 All proceeds of this NFT will be donated to Greg Fahy, a longevity researcher who has demonstrated human rejuvenation via thymus regeneration. This video documents the process of burning 2Tulips. Tulips are special to Adam, and their historical significance can’t be ignored. At one time in human history, you could buy land with tulips. The first time he saw tulips, they invoked a sense of awe, and
A Metabesity 2020 Emerging Company Showcase presentation on Intervene Immune by Greg Fahy, PhD, Co-Founder and CSO. Intervene Immune is developing treatments for thymus regeneration to help prevent or reverse age-related immune system decline. In the TRIIM pilot study, with collaborators at UCLA and Stanford, the company demonstrated significant reversal of immunosenescence and epigenetic aging, two leading risk factors for human morbidity and mortality. Currently, they are enrolling volunteers across the U.S. for a larger clinical trial, named TRIIM-X, that will include healthy men and women age 40 to 80. The company is beginning to partner with physicians, clinics, and medical centers who would like to offer treatment and to participate in future studies.
A Metabesity conference session answering the questions: What is needed to put biomarkers to work in therapeutic development, regulated product approval, and clinical management? How can we find reliable biomarkers of aging that predict and demonstrate effective interventions? What does/should a biological clock measure? Moderator: Morgan Levine, PhD, Assistant Professor of Pathology and Epidemiology at Yale School of Medicine Dan Belsky, PhD, Assistant Professor of Epidemiology at the Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University Bobby Brooke, MSc, CEO of Intervene Immune, Inc. and Executive Director of The Clock Foundation Daniel Ives, PhD, CEO of Shift Bioscience, UK Miсhelle Keller, Senior Manager of Scientific Business Development at Deep Longevity, Russia Jamie Justice, PhD, Assistant Professor at Wake Forest University School of Medicine Chris Leptak, MD, PhD, Senior Vice President, Drug and Biological Products at Greenleaf Healt
In this video Dr. Fahy shares his personal longevity protocol. And in particular talks about Carnosine, a supplement that I have not looked at before. Intervene Immune website: http://interveneimmune.com/ Contact to join the trial or invest http://interveneimmune.com/?page_id=1148 Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results. ******************************************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Produc
In this video Dr. Fahy shares his opinion on some of the up and coming anti-aging therapies, including NAD boosters, Hyperbaric Oxygen Chambers and senolytics. Some links are affiliate links so we will earn a commission when they are used to purchase products. Renue By Science 10% : Code MHS NMN https://tinyurl.com/3wr8pr3t DoNotAge 10% discount code MHS https://tinyurl.com/6dbvhv87 Bulletproof 15% off with coupon code: HEALTHSPAN15: https://tinyurl.com/4npjk5vp NOVOS Labs $5 discount Code 5OFFMHS24 NOVOS Core https://novos.sjv.io/AWv6QN, Vital https://novos.sjv.io/vNJd6y OmegaQuant 5% discount Code MODERN https://omegaquant.com/shop/ Wellness Extract 5% discount Code MODERN10 Geranylgeraniol Essential 1o1 Nitric Oxide 10% discount with code Modern https://tinyurl.com/3esakm4s Nitric Oxide Lozenges https://tinyurl.com/yh4rrtht Pendulum 20% discount code HEALTHSPAN Akkermansia https://pendulumtherapeutics.sjv.io/DK42Yd Intervene Immune website: http://interveneimmune.com/ C
In this video Dr. Fahy shares his opinion on some of the up and coming anti-aging therapies, including NAD boosters, Hyperbaric Oxygen Chambers and senolytics. Intervene Immune website: http://interveneimmune.com/ Contact to join the trial or invest http://interveneimmune.com/?page_id=1148 Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results. ******************************************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor fir
In this video Dr. Fahy discusses the next steps for TRIIM-X, how to participate and what to do if you would like to invest in Intervene Immune. Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results. ******************************************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer: Please note that we have full authorization
In this video Dr. Fahy discusses the TRIIM-X trial, which is the follow on to the original TRIIM trial. We discuss the differences from TRIIM and the current state of the trial. It is still open for enrolment! If you would like to enrol in the TRIIM-X trial please either email [email protected] or sign up on their website http://interveneimmune.com/?page_id=1148 You can read more details on trial and how to contact them from the trial page here: https://clinicaltrials.gov/ct2/show/NCT04375657#contacts Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results. ***************
In this video Dr. Fahy discusses growth hormone and it benefits in aging. He also covers the safety checks that they performed after the participants started with the protocol. In particular they saw reduced markers of cancer and cancer risk. Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results. ******************************************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video a
In this video Dr Fahy introduces the TRIIM trial and talks about the regimen of drugs that they use, why they choose the ones they did and the kind of personalization that they performed during the trial. Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results. ******************************************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyr
Host Linda Cooper interviews Dr. Greg Fahy, Chief Scientist and Founder of Intervene Immune on his unprecedented reversal of epigenetic aging by regenerating immune function via the Thymus proven in his TRIIM trial. Measured by Intervene Immune’s colleague Dr. Steve Horvath, the study demonstrated more than a two-year increase in predicted human lifespan utilizing all four Horvath Clocks. Taking "the science of aging out of the laboratory and into the real world" Host Linda Cooper interviews the elite handful of scientists making a direct impact to reverse the aging process. Welcome to THE NEW 100 LONGEVITY CAMPAIGN! The Future Is Now....
Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. In this short exert from our interview, Dr. Fahy talks about his pilot study, Thymic Rejuvenation and Immunorestoration and Insulin Mitigation, or the TRIIM trial. This trial was initially designed to test whether a cocktail of DHEA, metformin and growth hormone could rejuvenate the thymus. On further inspection, the team made the ground-breaking discovery, that the drug cocktail had wound back the biological age of the participants. In the full talk, Dr. Fahy discusses the groundbreaking moment they discovered the results of the TRIIM trial and whether they constitute true ageing reversal. He also delves into the details of TRIIM-X trial, changes to the protocol, going international and what success might look like. -------------------------------- Links for Dr
Seminar summary: https://foresight.org/summary/greg-fahy-intervene-immune-thymus-rejuvenation-progress-update/ Program & apply to join: https://foresight.org/biotech-health-extension-program/ Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital Greg Fahy, Intervene Immune Thymus Rejuvenation Progress Update - Designed and led the TRIIM trial; Published the first report of thymus regeneration in a normal human; Granted patents on methods for and applications of human thymus regeneration. - Fellow of the American Aging Association. (since 2005), Former Director of the American Aging Association (16 years) - Editor-in-Chief, The Future of Aging: Pathways to Human Life Extension. - Awarded the Society for Cryobiology’s Luyet Medal in 2016. - In 2009, showed indefinite survival of rabbit kidney transplanted after cooling to -130°Celsius; Led 21CM team as co-winner of Small Mammal Brain Preservation Prize, 2018 winner of Large Mammal Brain Preservation Prize. Greg
Over the last 150 years, our life expectancy has grown, from 40 years in 1850 to over 90 years today in some countries. This can be attributed to advances in medical science, improvements in public health, and equitable access to healthcare, especially for maternal and infant care. What does the future hold for longevity and ageing? According to the World Health Organisation, almost 70 percent of the population can expect to live longer than 85 years by 2050. Furthermore, by that time between 30% to 55% of the world's elderly will suffer from frailty. And if the right rejuvenation therapies are not used proactively in young and middle-aged people today, many of them will end up in their final years needing expensive medical care due to chronic diseases and disability. Reaching the goal of enhanced longevity requires a paradigm shift in science, both in terms of the conceptualization of ageing and how research funding and knowledge are directed. It also requires a shift in our per
The 1st Metchnikoff’s Day Online Conference “Aging, Immunity and COVID-19” May 16, 2020 Via ZOOM Organized by International Longevity Alliance (ILA) Conference program https://www.longevityforall.org/metchnikoff-day-may-15-online-conference-may-16/ Marking the 175th Years Anniversary of Elie Metchnikoff – The founder of gerontology and cell immunology – May 15, 2020. The lessons from history and hope for the future. Ilia Stambler (ILA) Fighting infections with Rejuvenation biotechnology. Aubrey de Grey (SRF) COVID-19 as an aging-related disease. Daria Khaltourina (ILA) Genetics of immunity and longevity. Alexey Moskalev (RAS) A survey for COVID-19 patients, treated or not, to investigate the effect of treatments. Harold Knoll / Edouard Debonneuil (ILA) What the response to COVID tells us about the politics of medical research. Josh Mitteldorf (Aging Matters) COVID-19, Immunosenescence, and T-cell Immunity. Robert Brooke (Intervene Immune, Inc.) Will daily COVID-19 deaths reach dail
The TRIIM-X trial is an expanded pilot clinical study that will evaluate a personalized combination treatment regimen for thymus regeneration. The thymus is a part of the immune system that declines markedly with age, and regenerating it may prevent or reverse key aspects of immunosenescence (immune system aging) and potentially prevent or reverse key parts of the aging process more generally. The study will evaluate biomarkers for epigenetic aging and immunosenescence, as well as evaluate established clinical measures and risk factors for prevention of physical frailty, cancer, cardiovascular disease, diabetes, dementia, and also infectious diseases, including flu and COVID-19. The study uses multiple agents in combination with personalized doses of recombinant human growth hormone (somatropin), metformin, and DHEA, in a similar manner to how the combination treatment was applied in the earlier TRIIM trial at Stanford, which demonstrated strong statistical significance for the primary efficacy endpoints that will be evaluated in TRIIM-X. Somatropin is approved by the FDA for adult growth hormone deficiency and its use in the study is guided by prior safety data established for that use and also based on safety data available on its prior use in the TRIIM trial and in clinical practice in healthy elderly individuals. There will also be control groups that enable testing of biomarker variability and the contribution of individual medications within the combination treatment. The objective of the study is to obtain information needed for designing an effective personalized and adaptive treatment regimen for a larger and more diverse study population, and to obtain additional proof of principle for the new use of the medications and biomarkers for preventive medicine. The duration of treatment in the TRIIM-X trial will be 12 months.
A study in California claims the body's biological, or epigenetic, clock can be set back by a couple of years. University of California researchers reversed the epigenetic clocks of 9 healthy white males by 2.5 years. Trial subjects received a combination of growth hormones along with 2 diabetes medicines for a year. Primary goal: To observe the safety and efficacy of using growth hormone to repair the thymus gland. The Thymus gland is located in the chest between the lungs and the breast bones. It is a vital cog of the human immune system. As humans age this gland starts to accumulate fat, thereby reducing immunity. The diabetes drugs were administered because growth hormones can promote diabetes. The results surprised the organiser of the study. Thy hoped for a slowdown in ageing, not a reversal. The immune response in these subjects also improved after the treatment The study began in 2015; it was led by immunologist Gregory Fahy, chief scientific officer and co-founder of Interv
Bobby Brooke, CEO of Intervene Immune, discusses the clinical potential of generating the thymus as a means of reversing age-related immune system decline. This talk was given at the Ending Age-Related Diseases conference in NYC. Join us at http://lifespan.io/hero ►Conference Page: https://www.leafscience.org/ending-age-related-diseases-advances-in-aging-research-and-investment-prospects/ ►Subscribe for more: http://www.youtube.com/user/LifespanIO?sub_confirmation=1 ►This video is presented by LEAF. Please support our work by becoming a "Lifespan Hero": http://lifespan.io/hero ► #LifeExtension #BobbyBrooke #InterveneImmune
In this panel, Dr. Oliver Medvedik of Lifespan.io/The Cooper Union, Dr. Michael West of AgeX Therapeutics, Kelsey Moody of Ichor Therapeutics, Stephen Hilbert of Oisin Biotechnologies, Dr. Sudhir Paul of Covalent Bioscience, Bobby Brooke of Intervene Immune, and Reason of Fight Aging! discuss their experiences in the creation of successful startup companies in the aging research sector. This panel was filmed at the Ending Age-Related Diseases conference in New York City. Join us at http://lifespan.io/hero ►Conference Page: https://www.leafscience.org/ending-age-related-diseases-advances-in-aging-research-and-investment-prospects/ ►Subscribe for more: http://www.youtube.com/user/LifespanIO?sub_confirmation=1 ►This video is presented by LEAF. Please support us by becoming a "Lifespan Hero": http://lifespan.io/hero ► #LifeExtension #Startups #StartupCompanies