NiaAge Biological Age Framework
exploratoryMeasure biological age in a clinically interpretable way by deriving biomarker contributions from non-linear associations with long-term mortality risk and aligning them with normative trajectories observed in healthy aging.
Biological-age model trained on 59 biomarkers from the 1999-2000 NHANES cohort and evaluated in the 2001-2002 NHANES cohort, spanning physiological domains such as hematology, metabolism, and inflammation.
medRxiv preprint published in 2026 reporting training and evaluation of the NiaAge framework.
NiaAge predicted long-term mortality, physical health, and cognitive health significantly better than chronological age; it outperformed several DNA-methylation age clocks on mortality and health-span metrics and performed comparably to leading physiological age clocks.