SC100 herbal longevity and stress-resistance supplement
preclinicalresearch program · high · Thu Jan 01 2015 00:00:00 GMT+0000 (Coordinated Universal Time)
Test whether a multi-path herbal intervention can extend lifespan and improve stress resistance in Drosophila.
Drosophila longevity, mortality, fertility, heat-stress, and partial-starvation assays using an herbal extract mixture predicted to affect aging and stress pathways including mTOR, NOS, NF-KappaB, and VEGF.
PLoS ONE publication in 2015 reporting lifespan and stress-resistance effects in Drosophila under some environmental conditions.
SC100 reduced mid-to-late-life mortality, increased stress resistance, and extended lifespan in some fly environments; effects declined or disappeared under minimized-stress conditions.
ReBuilder botanical supplement for Alzheimer's disease
undisclosedconsumer product · high · Tue Oct 01 2013 00:00:00 GMT+0000 (Coordinated Universal Time)
Evaluate whether adding a multi-pathway botanical dietary supplement to standard treatment regimens can improve or stabilize cognitive function in mild and moderate Alzheimer's disease patients.
Placebo-controlled, double-blind clinical study of an 8-component botanical supplement, ReBuilder, added to maximum tolerated standard Alzheimer's treatments.
ClinicalTrials.gov record published 2013-10-01 for mild and moderate Alzheimer's patients.
A listed publication states that a botanical mixture stabilized cognitive function in patients with mild and moderate Alzheimer's disease, but detailed results are not included in the supplied material.
Large-scale Drosophila drug-testing assay
exploratoryplatform · medium · Thu Jan 01 2009 00:00:00 GMT+0000 (Coordinated Universal Time)
Provide or validate a fruit-fly protocol for detecting long-term functional effects of candidate drugs and compounds.
Mixed-sex, high-density Drosophila cage assays designed to maximize reproductive opportunities and social interaction while measuring long-term functional side effects of compounds.
PLoS ONE publication in 2009 validating the protocol using genetic differences and stimulant/sedative comparisons.
The protocol distinguished long-term effects among caffeine, theobromine, lithium carbonate, and valproic acid in Drosophila, but the authors cautioned that findings do not directly imply human recommendations.
Drosophila high-density drug-testing assay program
exploratoryplatform · medium
Develop and validate a fruit-fly assay system for testing long-term functional effects of candidate drugs and compounds.
Mixed-sex, high-density Drosophila cage assays designed to measure chronic functional effects while preserving reproductive opportunities and social interaction.
2009 PLoS ONE publication validating the protocol with stimulants and sedatives including caffeine, theobromine, lithium carbonate, and valproic acid.
The protocol detected established genetic differences between outbred fly populations and distinguished long-term effects within stimulant and tranquilizer categories; the authors cautioned that findings do not directly apply to humans.
Drug development for chronic diseases of aging
undiscloseddrug program · medium
Develop novel therapeutics targeting chronic diseases of aging.
Evolutionary genomics, model-animal and human whole-genome analysis, massive selective screening, and fruit-fly longevity research used to inform therapeutic discovery.
Company drug-development page describes Genescient's development focus and use of its platform for drug development.
Methuselah flies evolutionary genomics platform
exploratoryplatform · high
Use long-lived fruit-fly populations and evolutionary genomics to identify genetic and network-level mechanisms relevant to aging and chronic diseases of aging.
Long-term Drosophila evolutionary selection, whole-genome analysis, model-animal genomics, and massive selective screening to inform drug development.
Genome-wide analysis of long-term evolutionary domestication in Drosophila melanogaster published in Scientific Reports in 2016.
The 2016 study found evidence consistent with selection acting on standing genetic variation and widespread selection signals, without clear hard selective sweeps.
SC100 herbal supplement longevity and stress-resistance program
preclinicalresearch program · high
Test whether a multipath herbal intervention can extend lifespan, reduce mid-to-late-life mortality, and increase stress resistance in Drosophila.
Drosophila longevity, mortality, fertility, starvation-resistance, and heat-stress assays using herbal extracts predicted to modulate aging and stress pathways including mTOR, NOS, NF-KappaB, and VEGF.
2015 PLoS ONE publication reporting Drosophila lifespan and stress-resistance results for SC100.
SC100 reduced mid-to-late-life mortality, promoted resistance to partial starvation and heat stress, and extended mean and maximum lifespan under some environmental conditions; effects declined or disappeared in a lower-stress independent test environment.
