C-6WKE

FILE C-6WKE·COMPANY·CURATED BY ETERNAL SEARCH

Heartseed Inc.

iPS cells, cardiac regenerative medicine, remuscularization

replacementreplacingcell therapy

heartseed.jp·Japan·Founded 2015·Public

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-6WKE

Projects

HS-001

undisclosed

drug program · high · Thu Jan 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

Treat severe heart failure by regenerating heart muscle with transplanted cardiomyocytes.

Allogeneic iPS cell-derived cardiomyocyte spheroids delivered into the myocardium. LAPiS evaluates transplantation in patients with underlying ischemic heart disease; EMERALD evaluates endocardial delivery in patients with reduced ejection fraction.

Clinical evaluation documented in the LAPiS and EMERALD study records, with safety and efficacy assessed over 26 weeks after transplantation. Trial phases are not supplied.

Autologous iPS cell research

exploratory

research program · medium

Explore autologous iPS cells for cardiac regenerative medicine.

Research using patient-derived iPS cells; specific experimental methods are not supplied.

Identified as a research direction in the supplied company site analysis.

HLA-knockout iPS cell research

exploratory

research program · medium

Explore HLA-knockout iPS cells for cardiac regenerative medicine.

Research using iPS cells with HLA knockout; specific editing methods and transplantation protocols are not supplied.

Identified as a research direction in the supplied company site analysis.

Metabolic profiling of cardiomyocyte grafts and teratomas

exploratory

research program · medium

Characterize metabolic maturation of transplanted iPS cell-derived cardiomyocytes and investigate detection of teratomas arising from residual undifferentiated cells.

RNA sequencing and imaging mass spectrometry of transplanted tissues, with [18F]fluorophenylalanine positron emission tomography for teratoma detection.

Research findings published in iScience in 2024; the supplied abstract does not establish a formally named company program.

Cardiomyocyte graft metabolism shifted from glycolysis toward fatty acid oxidation after transplantation. Teratomas showed increased amino acid transporter expression and amino acid accumulation. Subcutaneous teratomas derived from undifferentiated iPS cells were detectable in vivo using [18F]fluorophenylalanine PET.

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

Projects

HS-001

undisclosed

drug program · high · Thu Jan 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

Treat severe heart failure by regenerating heart muscle with transplanted cardiomyocytes.

Clinical evaluation documented in the LAPiS and EMERALD study records, with safety and efficacy assessed over 26 weeks after transplantation. Trial phases are not supplied.

Autologous iPS cell research

exploratory

research program · medium

Explore autologous iPS cells for cardiac regenerative medicine.

Research using patient-derived iPS cells; specific experimental methods are not supplied.

Identified as a research direction in the supplied company site analysis.

HLA-knockout iPS cell research

exploratory

research program · medium

Explore HLA-knockout iPS cells for cardiac regenerative medicine.

Research using iPS cells with HLA knockout; specific editing methods and transplantation protocols are not supplied.

Identified as a research direction in the supplied company site analysis.

Metabolic profiling of cardiomyocyte grafts and teratomas

exploratory

research program · medium

Characterize metabolic maturation of transplanted iPS cell-derived cardiomyocytes and investigate detection of teratomas arising from residual undifferentiated cells.

RNA sequencing and imaging mass spectrometry of transplanted tissues, with [18F]fluorophenylalanine positron emission tomography for teratoma detection.

Research findings published in iScience in 2024; the supplied abstract does not establish a formally named company program.