Ovarian networks reject isolated inputs

This hypothesis asks whether young ovarian non-egg-forming cells help control injury responses, prompted by mouse ovarian grafts' reported survival benefits. It predicts one strong injury signal is ignored while matching signals from several tissues trigger a response. In perfused multi-tissue cultures, total cytokine exposure, the amount of immune signaling proteins, would stay constant while one or several nodes are stimulated. Input sensing would then be disabled while basal secretion, background signal release, stays intact. This predicted culture pattern would support distributed signal integration, but leave rival explanations unresolved, including resolution after donor-cell death. It is required before animal studies of grafts with active or disabled sensing.