Neural retiming restores skin protection

This proposed hypothesis asks whether aging human skin could regain coordinated protection by retiming nerve signals, even when its nerve-fiber density stays low. The test holds fiber density, total nerve activity, inflammatory activity and the capacity of sweat glands and blood vessels to respond constant. It then compares tightly grouped signal-arrival times with timing jitter, meaning the same signals arrive less consistently. The model predicts that tighter timing would restore prompt protection, blood flow and sweating together; jitter would disrupt that coordination. Testing this requires synchronized recordings from nerve-connected skin preparations and prespecified response windows that can distinguish timing from competing explanations.