Mechanical history uncouples secretory functions

This hypothesis asks why sweating can stay impaired after skin stiffness recovers: can a sweat gland lose the pairing of two jobs its cells need to make fluid? Earlier mechanical loads may separate calcium entry, calcium flowing into a cell to start secretion, from calcium-dependent chloride conductance, cells passing chloride ions for fluid movement. Average function could appear normal although too few cells retain both jobs. The test would restore both functions in the same cells or different cells, hold load and duct openness equal, then measure primary secretion. Greater recovery from same-cell restoration would support the hypothesis; equal recovery would reject it. Water transfer in an intact duct could instead favour a duct-interface explanation.