Hormone priming shapes menopause responses

A proposed menopause study tests whether brief estrogen exposure shapes later treatment responses to guide treatment choice. Groups would receive estrogen or matched control. After verified clearance and baseline recovery, participants would independently receive endocrine treatment, acting through hormonal signalling, or nonendocrine treatment through another pathway. The study would compare objective responses. It proposes locus-specific transcriptional priming, a lasting DNA-site change altering later gene activity. A changed treatment contrast preceded by transcriptional recall would support priming. An interaction within a prespecified clinically meaningful equivalence margin would weaken it. Imprecise or overlapping patterns would leave explanations unresolved.