Cooling prolongs sweat secretion

Cooling may prolong sweating; this proposed study asks whether timing affects water loss and temperature stability. Isolated human eccrine glands, which make sweat, receive a stimulus. After confirmed removal, cooling before the response ends is predicted to prolong secretion. These glands lack neural control, so sensory encoding does not predict this response. M3 receptors, acetylcholine-responsive switches, are proposed to signal through Gq, an intracellular relay, in endosomes, membrane-bound compartments. Selectively suppressing that signal while preserving initial response tests the idea: loss of the cooling-order effect would support it; a persistent delay would weaken it.