Immune-clearance delays drive senescence recurrence

Age-related tissue damage may keep returning because immune cells arrive too late to clear senescent cells, cells that have stopped dividing but can disturb their neighbours. This proposed mechanism asks whether changing timing, rather than the amount of cell-killing activity, can quiet recurring waves. The test would begin after confirmed removal of chronically senescent cells. It would hold matrix composition, starting burden and total cytotoxic activity constant, then compare a shorter immune-response delay with the original delay. The hypothesis predicts damped recovery only when clearance arrives sooner. Persistent waves after verified correction would weaken timing mismatch as a sufficient explanation.