Bryan Johnson announces plans to model health trajectories

Bryan Johnson announces plans to model health trajectories

On October 21, Blueprint founder Bryan Johnson wrote that individual biomarkers, measurable indicators of the body's condition, capture only part of the aging process. He wants to combine repeated measurements into a model that predicts future health and responses to interventions.

Blueprint is Johnson's project for regularly measuring his own health. In his October 21 post, he described the limits of those measurements:

“My biomarkers tell us less than people think.”

A health trajectory is mapped through repeated observations: how a person's health changes over time, what happens after an intervention, and whether subsequent measurements confirm the predictions. In April, Johnson announced Autonomous Health, a program to regularly measure his own health. He now wants to use these measurements to predict how his health will change.

In their review, Ruqaiyyah Siddiqui and Naveed Ahmed Khan propose a digital twin of aging for this purpose: an individualized mathematical model. It links measured indicators to processes within the body, changes in those processes over time, and the effects of interventions. The model is tested by predicting a person's future health and response to an intervention, then comparing those predictions with new observations.

Johnson described Blueprint's goal as follows:

“To move from forecasting measurements to simulating the dynamics of the aging system: a person's future health trajectory.”