AEP inhibitor increased mean mouse lifespan and reduced frailty

AEP inhibitor increased mean mouse lifespan and reduced frailty

Mice given compound #11a in their food from 18 months of age lived for an average of 28 months, compared with 24 months in the control group. An assessment based on 29 signs of aging also found lower frailty in the treated animals.

#11a inhibits AEP, an enzyme that cleaves proteins. The experiment included normally aging mice, with 26 animals in each group. Earlier studies by the same research group had used genetically modified mice. Some animals in the new experiment were euthanized at 23 months for tissue analysis and excluded from the death count.

The researchers assessed the mice using a Frailty Index, a combined score of age-related impairments. In this experiment, it covered 29 signs, including impaired hearing and gait, and cataracts. The Eternal Search page linked below explains the term.

Scores were lower in both male and female mice receiving #11a. The researchers assessing the animals did not know which mice had received the compound. After five months of treatment, at 23 months of age, these mice also ran longer on a treadmill before falling and hung longer from an inverted grid.

These measurements show improvements in the animals' condition, but they cannot establish how many additional months the mice lived in good health. The supplied report gives no numerical size for the reduction in frailty score. This experiment also provides no evidence of rejuvenation in humans.

The reasons for the increase in lifespan remain uncertain. During the first five months, the difference in food intake was not statistically significant, although some measurements showed lower intake in cages receiving #11a. The authors acknowledge that this may have affected lifespan, so part of the observed benefit could have come from eating less.

Open the related Eternal Search page

Sources
[1] cell.com
[2] pmc.ncbi.nlm.nih.gov
[3] pmc.ncbi.nlm.nih.gov
[4] t.me