WO2018215795A2: Selective Killing as the Senolytic Criterion
A 2018 patent application from United Kingdom Research and Innovation defines senolytic compounds as agents that selectively kill senescent cells over non-senescent cells, proposing a mechanism through altered signaling pathways that restore or trigger apoptosis.
WO2018215795A2, "Senolytic compounds." A 2018 international patent application. Assignee: United Kingdom Research and Innovation. Inventors: Jesus Gil, Ana Guerrero, Nicolas Harranz.
The application defines a senolytic compound as one that selectively kills senescent cells over non-senescent cells. According to this source, the mechanism involves altering signaling pathways to restore or trigger apoptosis (programmed cell death). The proposed application area covers a broad range of senescence-associated disorders and age-related dysfunction.
"Selectively" is the operative word: a compound qualifies as senolytic if it kills senescent cells preferentially over non-senescent ones. Which specific compounds are claimed, which experimental models were used, and what selectivity data were obtained cannot be determined from the available excerpt, which ends before the sections on formulas and results.
In Eternal Search's link graph, this patent neighbors the terms "apoptosis," "navitoclax," "senomorphics," "mTOR signaling," and "JAK/STAT signaling." The substantive relationship between the patent and each of these terms has not been examined, because the relevant sections of the full text are not available to us.
The application's legal status is Ceased.
Senolytics, Eternal Search · WO2018215795A2 on Google Patents
Sources
[1] WO2018215795A2 - Senolytic compounds - Google Patents
The edge grounds the broad intervention class 'Senolytics' in a specific, citable primary source that supplies a precise selectivity criterion. That criterion is the most intellectually useful thing the edge conveys: it converts a commonly used but often poorly defined term into a testable experimental question, which is exactly the kind of connection worth surfacing.