2003: TOR Signaling Linked to Aging in Nematodes
The Wikipedia timeline of aging research records the first evidence in 2003 that TOR signaling regulates aging in nematodes.
In 2003, researchers produced the first evidence that TOR signaling regulates aging in nematodes. The "Timeline of aging research," a Wikipedia chronology of milestones in aging science, records this result. The entry does not describe the experiment: the authors, the TOR complex involved, the nematode species, the direction and magnitude of the effect are all unspecified. The original 2003 study could not be identified from the available excerpt.
mTOR signaling (mechanistic target of rapamycin) is a nutrient- and growth-responsive pathway that regulates cell growth, protein synthesis, and autophagy.
mTOR Signaling, Eternal Search
Sources
[1] Timeline of aging research - Wikipedia
This edge anchors a specific dated claim (2003 nematode TOR evidence) to a central pathway node with high graph confidence, making the connection concrete and historically grounded rather than thematically vague.