Jamie Justice and Caloric Restriction
Jamie Justice's profile references an 18-week caloric restriction trial in 58 adults with obesity and prediabetes (10.8 kg mean weight loss, circulating SASP factors measured), but her role in the trial and the significance of the SASP-factor changes for biological aging are not established.
Jamie Justice is Executive Vice President of the Health Domain at XPRIZE and an adjunct professor at Wake Forest University School of Medicine. Her work centers on biomarkers and clinical trials in geroscience (the science of aging).
Her profile references an 18-week randomized trial of 58 middle-aged and older adults with obesity and prediabetes; mean weight loss was 10.8 kg. Beyond weight, the trial measured changes in circulating SASP factors (senescence-associated secretory phenotype). Caloric restriction in this context means reduced calorie intake with adequate nutrition maintained.
Justice's specific role in that trial is not established from available data. The direction of the SASP-factor changes and their clinical significance are also unknown: the publication is not named, and the details cannot be verified without the original paper.
The edge links a geroscience clinical-trial researcher to a dietary intervention via a concrete trial result, while the gaps in what the connection establishes make it a useful example of how the graph captures associations without confirming mechanism or authorship.