AMPK and the 2004 Nematode Entry
The Wikipedia Timeline of aging research records a 2004 finding that AMP-kinase regulates nematode aging, but the study's authors, design, and mechanism are not established from the available data.
The Wikipedia article "Timeline of aging research" dates to 2004 the first evidence that AMP-kinase regulates aging in nematodes.
AMPK (AMP-kinase) is a signaling pathway that responds to cellular energy deficit. Under low-energy conditions, it promotes catabolic metabolism and stress adaptation.
The authors, study design, and specific mechanism are not established from the data available to us. Whether AMPK activation extended nematode lifespan, was required for another longevity intervention, or affected aging through a different mechanism is unknown. Our hypothesis is that this result first linked cellular energy sensing with the molecular mechanisms of aging, but the primary source is needed to verify that.
More on the pathway: AMPK Signaling. The 2004 entry: Timeline of aging research (Wikipedia).
Sources
[1] Timeline of aging research - Wikipedia
High-confidence edge (0.99) anchored to a concrete historical year and a well-defined molecular pathway, producing a specific and verifiable claim; the honest gap around the underlying study makes it an invitation to follow the primary source rather than a dead end.