uPAR-Targeted T Cells as Senolytics
A patent application describes uPAR-targeted T cells as senolytics, but the available excerpt does not show the evidence needed to assess their selectivity.
T Cells Targeting Senescent Cells
The patent application Senolytic CAR T Cells Targeting uPAR, a Cell Surface and Secreted Senescence Biomarker describes T cells with a chimeric antigen receptor directed at uPAR. The title identifies uPAR as a marker of cellular senescence found on the cell surface and secreted by cells.
The authors call these T cells senolytics that act within a living organism. Senolytics are intended to selectively eliminate senescent cells, meaning cells in a state of cellular senescence, while sparing other cells. The available excerpt contains the authors' claim but does not show the experimental models, control groups, or results. Assessing selectivity requires checking the full document for evidence of senescent cell removal and effects on other cells that express uPAR.
Sources
[1] US20220098320A1 - Senolytic car-t cells targeting upar, a cell ...
This edge gives a concrete example of cellular senolysis and directs readers to the decisive evidence question: whether uPAR targeting removes senescent cells selectively.