Guido Kroemer
Kroemer helped define how aging research understands autophagy, metabolism, and cell death. His 2,322 papers have drawn more than 383,000 citations.
Профиль
Professor and physician-scientist in Paris whose research has defined mechanisms of cell stress and death, autophagy, metabolism, cancer, inflammation, and aging.
Role
scientisthigh confidence
Kroemer is an author on peer-reviewed papers directly linking autophagy and metabolic mechanisms to tissue homeostasis and healthspan, including as author of highly cited aging work. His research is the evidenced channel through which he advanced longevity.
Разбивка по измерениям
Этот балл оценивает только приверженность долголетию. Метки роли выше — scientist, investor и остальные — показывают, кем является этот человек; мы не оцениваем их отдельно.
Видение будущего
4.0/ 10
Kroemer articulates several concrete, mechanistically grounded paths for improving healthspan and addressing age-related decline, especially through autophagy, stress resilience, gerodiagnostics, and precision geromedicine. However, the evidence does not show a clear overarching destination, timeline, or publicly consistent commitment to ending aging, reversing aging broadly, or materially extending human lifespan.
medium уверенность
Научное влияние
10.0/ 10
Exceptional citation-weighted evidence demonstrates field-defining scientific influence across aging, autophagy, cell death, metabolism, and cancer biology. The combination of an h-index of 286, 383,433 citations, and numerous foundational papers with thousands of citations warrants the maximum score.
high уверенность
Вложенный капитал
Неприменимо
The evidence establishes substantial scientific output but provides no capital-deployment activity to evaluate. Scientific publications and citations are not substitutes for investments or donations under this dimension.
No public capital deployment activity is evidenced for this scientist: no investments or donations were found.
high уверенность
Качество стратегических решений
4.0/ 10
Kroemer’s sustained work linking autophagy, metabolism, cell death, cancer, immunity, and aging suggests a coherent scientific thesis with major field influence. However, the supplied evidence does not establish that he selected these directions unusually early, against prevailing views, or with clear counterfactual importance. The record supports promising mechanistic and translational choices, but not a high-confidence account of strategic taste.
low уверенность
Создание направления
1.0/ 10
The dimension is applicable, but the supplied evidence shows scientific discoveries and ongoing research rather than creation of organizations, programs, communities, protocols, categories, or funding paths that enabled longevity work for others.
high уверенность
Смелость и убеждённость
3.0/ 10
There is limited evidence of public contrarian conviction: Kroemer co-authored a paper advocating avoidance of widely used benzodiazepines in sepsis-heavy intensive-care populations. However, the record does not establish substantial personal risk, career sacrifice, sustained resistance to serious criticism, a large capacity-relative bet, or self-experimentation.
low уверенность
Эффект множителя
8.0/ 10
Exceptional citation reach and multiple highly cited field-shaping papers demonstrate substantial second-order leverage through knowledge diffusion, collaborator networks, and follow-on research. However, the evidence does not establish comparable leverage through organization-building, talent development, capital, policy, or public mobilization.
medium уверенность
Видение будущего
Цель
No canonical quotes yet.
Путь
These findings position DBI/ACBP as a metabolically relevant autophagy-associated regulator in ciliopathy and suggest that therapeutic benefit can be achieved by targeting autophagy-linked effectors without directly correcting autophagic flux.
Here, we propose hierarchical composite endpoints using time-to-worst-event analysis as a pragmatic and scientifically sound compromise.
Together, these findings support a unified model in which spermidine-driven autophagy and spermine-mediated ferroptosis inhibition cooperate to preserve tissue homeostasis and healthspan.
We propose that replacing benzodiazepines with alternative sedative strategies may improve both short-term outcomes and long-term trajectories of post-sepsis disability.
Precision geromedicine therefore requires the integration of gerodiagnostics that capture system-level resilience and stress responsiveness with measures of functional reserve, behavior, physiology, and the exposome, enabling the identification of individualized aging trajectories and the biological pathways that drive them.
Стратегия
No investment, donation, organization-building, or project evidence establishes a strategic deployment thesis [S1]. Kroemer’s documented research spans autophagy, metabolism, cell stress and death, cancer, inflammation, and aging [S1]. The evidence does not support a stage preference, risk appetite, geographic focus, or time horizon [S1]. No notable bets or evidence-backed collaborators can be identified from the supplied material [S1].
UnknownUnknownAutophagyMetabolismCell Stress And DeathCancer And InflammationAging
Портфель
Инвестиции
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Пожертвования
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Основанные организации
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Научные результаты
h-index286
Citations-
Papers27
Trials0
Смелость и убеждённость
Критика