{ "protocol": "balanced-confirmation-v1", "model": "gpt-6-astra", "cohortSha256": "4f247b703f31db077e6e403dcd1adc1de79bf53a9ef12c6a94775850168b445e", "samples": [ { "task": "H556eb44d6587", "mapping": [ { "id": "H556eb44d6587" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H556eb44d6587] Global Gcgr deletion increases sperm concentration in male mice relative to wild-type littermates.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H556eb44d6587" ], "promptChars": 305, "promptSha256": "301ec03bc09c74cf926bc4099fc93e78a7c637650206e7ef85880043a3a84771" } ] }, { "task": "Hf84dc04d9967", "mapping": [ { "id": "Hf84dc04d9967" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hf84dc04d9967] The STING inhibitor H-151 at 25 mg/L in drinking water extends male Lmna-G609G progeroid mouse median lifespan relative to vehicle.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hf84dc04d9967" ], "promptChars": 338, "promptSha256": "bb2d8753ac5d060dce881c609d28906214bd3352c43718beacf03757c6c8d097" } ] }, { "task": "Hd366df6c0c2d", "mapping": [ { "id": "Hd366df6c0c2d" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hd366df6c0c2d] Hepatocyte-specific GHR deletion extends male mouse lifespan relative to floxed littermate controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hd366df6c0c2d" ], "promptChars": 307, "promptSha256": "4aa35dad4f2de7b6c89064a7dd98d04f6c968851f7109ca0d7dfbbb3b33b16c7" } ] }, { "task": "Hca5687df1d17", "mapping": [ { "id": "Hca5687df1d17" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hca5687df1d17] Twelve weeks of dietary coenzyme Q10 increases bone-marrow megakaryocyte colony counts in twelve-month-old mice relative to unsupplemented controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hca5687df1d17" ], "promptChars": 355, "promptSha256": "a515b43852345b31d4fcfc961e38cb69b40757640dd62ce52e467d8108d8c497" } ] }, { "task": "H00754d90403e", "mapping": [ { "id": "H00754d90403e" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H00754d90403e] Co-culture with sardomozide-pretreated fibro-adipogenic progenitors increases nuclei per myotube during mouse muscle stem cell differentiation relative to untreated-progenitor co-culture.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H00754d90403e" ], "promptChars": 394, "promptSha256": "f64e60203d8cfdf89c2faeeebc91d2caf6a93a4aabd85f828ea205215834b5bb" } ] }, { "task": "H7b5933386c64", "mapping": [ { "id": "H7b5933386c64" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H7b5933386c64] Dasatinib plus quercetin increases mineralized callus bone volume twenty-eight days after fracture in mice lacking Cbfb in Adipoq-positive marrow cells relative to untreated knockout mice.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H7b5933386c64" ], "promptChars": 395, "promptSha256": "db41dae8540dbcac2e10af95560c5042f58075aed55d0842184c42b240412d86" } ] }, { "task": "H9cb69403e6d8", "mapping": [ { "id": "H9cb69403e6d8" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H9cb69403e6d8] ALDH6A1 overexpression increases Transwell migration of human AGS gastric cancer cells relative to vector controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H9cb69403e6d8" ], "promptChars": 322, "promptSha256": "6363d2a6928489ef37cd3fde890ed3a067f3d921541535c0df09675286d5c81e" } ] }, { "task": "H3d94392f96ae", "mapping": [ { "id": "H3d94392f96ae" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H3d94392f96ae] Grtp1 deletion increases the percentage of progressively motile sperm in three-to-four-month-old male mice compared with age-matched wild-type controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H3d94392f96ae" ], "promptChars": 359, "promptSha256": "47a09d853eafb91bc934c0e717f5d2d2464f72273e22dd868963e6e6615d819d" } ] }, { "task": "H591cc6bdd061", "mapping": [ { "id": "H591cc6bdd061" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H591cc6bdd061] Induced NICD expression prevents depletion of Pax7-positive muscle stem cells in Kmt5a-deficient adult mice twenty-one days after muscle injury.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H591cc6bdd061" ], "promptChars": 351, "promptSha256": "544673de3c6faf8a1e439a7865554137789036fd3cea4384dbcaca12f6912c3c" } ] }, { "task": "H699141a0e533", "mapping": [ { "id": "H699141a0e533" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H699141a0e533] Deleting guanylyl-cyclase-A receptors in adrenal zona-glomerulosa cells reduces the blood-pressure increase induced by two weeks of 4% dietary salt in mice.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H699141a0e533" ], "promptChars": 363, "promptSha256": "a4dcf29327620e9b7b4807f573318ef65e5425f72d9605dd165d6d13201f115a" } ] }, { "task": "H2a068a10286e", "mapping": [ { "id": "H2a068a10286e" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H2a068a10286e] Hepatocyte-specific Sirt6 deletion lowers hepatic Cdkn1a expression in aged female mice relative to floxed controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H2a068a10286e" ], "promptChars": 323, "promptSha256": "fb0c03917d3f91d85adcd7c95d09686b87ac4c5047ada3facd668d450b158c1a" } ] }, { "task": "H5ae76ff04768", "mapping": [ { "id": "H5ae76ff04768" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H5ae76ff04768] Fgf21 knockout lowers uterine interleukin-1 beta protein after intrauterine lipopolysaccharide challenge in mice relative to challenged wild-type controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H5ae76ff04768" ], "promptChars": 362, "promptSha256": "d3b62f156b0d2b6c48163ca9d825e553cd5c0174858daf734e4bace67017d329" } ] }, { "task": "H9cc800ed9167", "mapping": [ { "id": "H9cc800ed9167" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H9cc800ed9167] Inducible cartilage-specific Erk5 deletion lowers knee cartilage OARSI damage scores after destabilization of the medial meniscus in adult mice relative to controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H9cc800ed9167" ], "promptChars": 372, "promptSha256": "c186b3498b1fa2dee6935d3c267302ef5e14eaa4c84949b3cb6181f378364296" } ] }, { "task": "Hc35db8c00454", "mapping": [ { "id": "Hc35db8c00454" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hc35db8c00454] Whole-body Ghr ablation initiated at twelve months increases male mouse body weight at nineteen months relative to controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hc35db8c00454" ], "promptChars": 331, "promptSha256": "d47a9b520565c9adfbbc4da230c79cff2429d51e5c148d3f4996d3b9dcd6f2e1" } ] }, { "task": "Hb19a1eaedf6f", "mapping": [ { "id": "Hb19a1eaedf6f" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hb19a1eaedf6f] Cbfb deletion in Adipoq-positive marrow cells increases PDGFR-alpha-positive skeletal progenitor abundance in mice relative to control mice.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hb19a1eaedf6f" ], "promptChars": 347, "promptSha256": "790150616aab43a699905b80ecdd3b30c1536b5f097de39f7eb8e3e42f44b512" } ] }, { "task": "Ha6af01b29947", "mapping": [ { "id": "Ha6af01b29947" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Ha6af01b29947] Adding chloroquine to SDF-1-treated aged mouse oocytes decreases G3BP1 fluorescence relative to SDF-1 alone.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Ha6af01b29947" ], "promptChars": 315, "promptSha256": "fdcc239b948664de91811ba8f14e4845781dfbd78a5ce4a5638d413a6eb612bc" } ] }, { "task": "H2d91f2d3ca48", "mapping": [ { "id": "H2d91f2d3ca48" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H2d91f2d3ca48] Adding L-glutamine restores apoptotic-cell engulfment by Slc1a5-deficient mouse bone-marrow-derived macrophages relative to unsupplemented deficient macrophages.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H2d91f2d3ca48" ], "promptChars": 368, "promptSha256": "9945c097181ec2b7dd91ecc45adf279ef4ba05aad496e254ab81e5fa1b2db3fc" } ] }, { "task": "Hbb8d36395a4f", "mapping": [ { "id": "Hbb8d36395a4f" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hbb8d36395a4f] Sardomozide inhibition of AMD1 increases Cdkn1a expression in fibro-adipogenic progenitors isolated from young mouse skeletal muscle relative to untreated progenitors.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hbb8d36395a4f" ], "promptChars": 374, "promptSha256": "d33859a08ec942f49b745188c35bbfec8b200ff34449822cf3528178a997ed66" } ] }, { "task": "Hdc04751acc25", "mapping": [ { "id": "Hdc04751acc25" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hdc04751acc25] Induced NICD expression preserves the quiescent Pax7-positive muscle stem-cell pool in Kmt5a-deficient adult mice six weeks after tamoxifen under homeostasis.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hdc04751acc25" ], "promptChars": 365, "promptSha256": "2062ca23f3ad2ecd6a0730a3d10e4f43f515153c0d4f486ba3c62a4fcb929be7" } ] }, { "task": "H0b95ea5bca8b", "mapping": [ { "id": "H0b95ea5bca8b" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H0b95ea5bca8b] Taurine supplementation lowers serum LDL cholesterol in hypothyroid rats relative to hypothyroid rats receiving water alone.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H0b95ea5bca8b" ], "promptChars": 331, "promptSha256": "5c0bafd3d794233040c07e53438ff1cdf4e9fb213f3e58aa7cdc34b7b2290693" } ] }, { "task": "Hc51c63819170", "mapping": [ { "id": "Hc51c63819170" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hc51c63819170] T-cell-specific Lmna deletion improves female MCA205 tumor-bearing mouse survival during combined oxaliplatin, anti-PD-1 and anti-ACBP/DBI treatment compared with T-cell-Lmna-sufficient controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hc51c63819170" ], "promptChars": 402, "promptSha256": "2d617f8097bf920c39c1af1135354e0b7e30070e53e68e939409cc23953dca37" } ] }, { "task": "Hbcb2664c171e", "mapping": [ { "id": "Hbcb2664c171e" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hbcb2664c171e] Seven days of 20 micromolar XL20 reduces dendritic spine density in human induced-pluripotent-stem-cell-derived motor neurons with TDP43-Q331K relative to vehicle-treated mutant neurons.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hbcb2664c171e" ], "promptChars": 393, "promptSha256": "a092175516696c669e5739277f411cffdd91a48d6da4390e5fa3d27d44d071c9" } ] }, { "task": "Hd41fa6090167", "mapping": [ { "id": "Hd41fa6090167" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hd41fa6090167] Snca deletion reduces whole-aorta atherosclerotic lesion area in male mice after AAV-PCSK9 administration and sixteen weeks of high-cholesterol feeding relative to wild-type littermates.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hd41fa6090167" ], "promptChars": 393, "promptSha256": "0e1663295fdd2e17ca98c2ae29a58991c5c92b0ff819ff65d72cd14ea22f1ae3" } ] }, { "task": "H108fec88412d", "mapping": [ { "id": "H108fec88412d" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H108fec88412d] Enzymatically hydrolyzed eggshell membrane increases KRT1 expression in cultured neonatal human epidermal keratinocytes compared with untreated cells.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H108fec88412d" ], "promptChars": 357, "promptSha256": "39993f33c544e5b39299d4ae537297ad884bc4428bbd83da4d373110895ab6f4" } ] }, { "task": "H5401e2f1476e", "mapping": [ { "id": "H5401e2f1476e" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H5401e2f1476e] Pdha1 silencing decreases lactate production in D-galactose-treated primary mouse pulmonary endothelial cells relative to control silencing.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H5401e2f1476e" ], "promptChars": 347, "promptSha256": "8ec853e057ce93945cab90ff8e302a38ec9b69ab8f916afc74f7ffcd61b0d19c" } ] }, { "task": "H8856cfb6fb8c", "mapping": [ { "id": "H8856cfb6fb8c" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H8856cfb6fb8c] Sost deletion increases tibial cortical thickness in seventy-eight-week-old mice relative to littermate controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H8856cfb6fb8c" ], "promptChars": 320, "promptSha256": "55666c545fe1194160a3cb3fc62fe188e469f489143e8000d36c6351ca7c3b59" } ] }, { "task": "H7d64d0c884ee", "mapping": [ { "id": "H7d64d0c884ee" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H7d64d0c884ee] Recombinant human FGF21 administered before intrauterine lipopolysaccharide lowers uterine histopathological injury scores in mice compared with lipopolysaccharide alone.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H7d64d0c884ee" ], "promptChars": 377, "promptSha256": "aec58422796370ea6b3a8d48edf6919588f839023d47e1cee42c83606f97a225" } ] }, { "task": "Hd2867abf0b74", "mapping": [ { "id": "Hd2867abf0b74" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hd2867abf0b74] FNDC1 overexpression restores EdU-labelled proliferation in ZBED6-overexpressing primary porcine muscle satellite cells relative to ZBED6 overexpression alone.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hd2867abf0b74" ], "promptChars": 366, "promptSha256": "d909f4dacb544a6f9efdcd88c6959aae13ffee8bd6c764fdae7f08828b9111ab" } ] }, { "task": "Hde2c7f764541", "mapping": [ { "id": "Hde2c7f764541" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hde2c7f764541] Conditional beta-PIX deletion in alveolar type-II cells increases the alveolar type-I to type-II cell ratio four weeks after induction in mice relative to wild-type controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hde2c7f764541" ], "promptChars": 381, "promptSha256": "3d10bccc8eab42471bddc527a258bdeb7ec45b0d58a627d7c38ff8349c0d90d1" } ] }, { "task": "Hb84019cbdccd", "mapping": [ { "id": "Hb84019cbdccd" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hb84019cbdccd] Psme4/PA200 deletion increases lung p53 protein in middle-aged mice subjected to urethane-induced tumorigenesis compared with wild-type controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hb84019cbdccd" ], "promptChars": 352, "promptSha256": "0eed29e6c49e6ef8959b40821a4f9a56fe378b77c422c9b175e641e0a6bc72d8" } ] }, { "task": "Hd06b5abc8c17", "mapping": [ { "id": "Hd06b5abc8c17" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hd06b5abc8c17] Endothelial-specific Pdha1 deletion lowers pulmonary endothelial p21 expression in D-galactose-treated mice compared with treated control littermates.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hd06b5abc8c17" ], "promptChars": 357, "promptSha256": "68bd3ec208bdcc13a05ebebe7cb4697b5125022259a7e87ed20614a7c526e2f3" } ] }, { "task": "Ha8f158ded9d3", "mapping": [ { "id": "Ha8f158ded9d3" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Ha8f158ded9d3] Intra-articular PAMAM-Chol-AZ3451 nanoparticles reduce mechanical allodynia twenty-four hours after treatment in mice with monoiodoacetate-induced knee osteoarthritis relative to vehicle.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Ha8f158ded9d3" ], "promptChars": 394, "promptSha256": "293a291c2f921a02a082af1c910bb7f6443d72e48b14e7cb26ab7801827dab77" } ] }, { "task": "H6e57c7188991", "mapping": [ { "id": "H6e57c7188991" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H6e57c7188991] Renal-tubule-specific Erbin deletion reduces serum creatinine one day after kidney ischemia-reperfusion in mice relative to control littermates.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H6e57c7188991" ], "promptChars": 351, "promptSha256": "0fcbda6b519fdaaf5e0c3f5b5791903f354e392c5b76519da8cab1e4c2d2bef8" } ] }, { "task": "H69deb1edcdbe", "mapping": [ { "id": "H69deb1edcdbe" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H69deb1edcdbe] TRPV4 knockout increases the phosphorylated-Akt to total-Akt ratio in mouse skin after seven days of topical imiquimod relative to treated wild-type controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H69deb1edcdbe" ], "promptChars": 365, "promptSha256": "aea9e23f8f11f51cfd944fff2a34b76670a9d2b59f22ef973e97f829d6618572" } ] }, { "task": "H770b494c23de", "mapping": [ { "id": "H770b494c23de" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H770b494c23de] Adenoviral Erbin overexpression in kidney cortex before ischemia-reperfusion reduces renal interstitial collagen deposition fourteen days after injury relative to control adenovirus in mice.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H770b494c23de" ], "promptChars": 397, "promptSha256": "59ce4f9354b6d18296d45bdb2e3c40955209ae907f1eb80ff1dcbc20fa05aaba" } ] }, { "task": "Ha24c224c2c5c", "mapping": [ { "id": "Ha24c224c2c5c" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Ha24c224c2c5c] Deleting membrane-bound COMT increases basal CellROX oxidative-stress signal in rat PC12 cells relative to wild-type cells.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Ha24c224c2c5c" ], "promptChars": 330, "promptSha256": "891f058e7cc7fc9d9e1f1c52ed5cec7d27b3ed3bb748d2295c45b33111b31752" } ] }, { "task": "H312a9208a0df", "mapping": [ { "id": "H312a9208a0df" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H312a9208a0df] Two weeks of alternate-day fasting before carbon-tetrachloride challenge reduces subsequent mouse liver fibrosis relative to freely fed controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H312a9208a0df" ], "promptChars": 352, "promptSha256": "60b8407aaa1ca2e741b3046b36cbffbe28f032d6524ebe511054b10e0084ace1" } ] }, { "task": "Hdd257b1a803d", "mapping": [ { "id": "Hdd257b1a803d" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hdd257b1a803d] Beta-cell-specific Fmo3 deletion improves glucose tolerance in twelve-week-old mice relative to wild-type littermates.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hdd257b1a803d" ], "promptChars": 325, "promptSha256": "9664f165dd4af2c1c614c273ecc713c1cb721dbd3a5348305e9cdaac70a53d47" } ] }, { "task": "H5a66cc1d176d", "mapping": [ { "id": "H5a66cc1d176d" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H5a66cc1d176d] Nox4 overexpression in brain endothelial cells further reduces hippocampal sodium-fluorescein leakage after anesthesia and surgery in endothelial-Piezo1-knockout mice relative to control virus.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H5a66cc1d176d" ], "promptChars": 400, "promptSha256": "8812bd61d5e627d7680bfb118a4cdb7ca7ae6ce52e100714929871b0640539a6" } ] }, { "task": "Hf40c85e4b441", "mapping": [ { "id": "Hf40c85e4b441" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hf40c85e4b441] Prx1-lineage Egfr deletion increases the fracture-callus bone-volume fraction at twenty-eight days after femoral fracture in mice relative to wild-type controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hf40c85e4b441" ], "promptChars": 368, "promptSha256": "eca839abd7a8b39c80617c682db007e051c6b093df22ae956abab5cda44e702e" } ] }, { "task": "H2bf61d6a2dae", "mapping": [ { "id": "H2bf61d6a2dae" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H2bf61d6a2dae] PAPPA overexpression reduces apoptosis caused by miR-27b-3p mimics in KGN granulosa cells exposed to 4-vinylcyclohexene diepoxide relative to empty vector.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H2bf61d6a2dae" ], "promptChars": 362, "promptSha256": "63ae6c9b371975a43ee93d8af8890fa58b88188bbf3fc2c61b1f15707b380f40" } ] }, { "task": "H69d1974ef6f3", "mapping": [ { "id": "H69d1974ef6f3" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H69d1974ef6f3] miR-27b-3p mimic transfection increases secreted IGF-1 in 4-vinylcyclohexene-diepoxide-injured KGN granulosa cells relative to scrambled controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H69d1974ef6f3" ], "promptChars": 353, "promptSha256": "5987212fe67372fe1e3421aa06e0d3d9660cb17db783648c79cc3896cc5ed2d7" } ] }, { "task": "Hca11ba345120", "mapping": [ { "id": "Hca11ba345120" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hca11ba345120] Twenty-four-hour atrial natriuretic peptide pretreatment attenuates angiotensin-II-induced ERK phosphorylation in human H295R adrenal cells compared with angiotensin II alone.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hca11ba345120" ], "promptChars": 382, "promptSha256": "77b49ec385f7a71a559680e29a9e7aa7cc3ba3b85dc1577caacfd7c81bddb33f" } ] }, { "task": "H9512eff47edd", "mapping": [ { "id": "H9512eff47edd" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H9512eff47edd] Whole-body Ghr ablation initiated at twelve months improves insulin sensitivity in male mice at twenty-three months relative to controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H9512eff47edd" ], "promptChars": 344, "promptSha256": "97197b3b3b3bc489f51923118acd7c234199346953190653c572bbaacd7be4e1" } ] }, { "task": "H3525a80080db", "mapping": [ { "id": "H3525a80080db" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H3525a80080db] Chronic diosmin supplementation increases plasma malondialdehyde in aged rats relative to vehicle-treated aged rats.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H3525a80080db" ], "promptChars": 323, "promptSha256": "9f9add2090505bc1a6fff130f36ddbea1709189d7d10d919282b5cfb8d8a7f29" } ] }, { "task": "H1ca81581ce0f", "mapping": [ { "id": "H1ca81581ce0f" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H1ca81581ce0f] Twenty-eight days of HFI-419 treatment preserves glomerular filtration in twenty-seven- to twenty-eight-month-old wild-type mice relative to vehicle treatment.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H1ca81581ce0f" ], "promptChars": 366, "promptSha256": "74329edcc6be38e8fb62baf672e313fccd141c653e8be70a4ff73c8e58dd0930" } ] }, { "task": "Hface15f9c0aa", "mapping": [ { "id": "Hface15f9c0aa" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hface15f9c0aa] Esr1 knockdown increases Sirt1 gene expression in differentiated C2C12 myotubes relative to control siRNA.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hface15f9c0aa" ], "promptChars": 313, "promptSha256": "eec69d2f9f68addd7e20f56149bfcc81342fab9fa7c948b7849cdcdf6ef3e7ae" } ] }, { "task": "He22abf94c32e", "mapping": [ { "id": "He22abf94c32e" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[He22abf94c32e] XL20 at 50 mg/kg intraperitoneally three times weekly starting at forty-five days extends survival in male TDP43-A315T transgenic mice relative to vehicle.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "He22abf94c32e" ], "promptChars": 362, "promptSha256": "1ab05a7d9e2e6eb78005533f80f2917251058b0d6d3b40c430c401e8d12f2085" } ] }, { "task": "H27c93d908b66", "mapping": [ { "id": "H27c93d908b66" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H27c93d908b66] LSD1 overexpression accelerates gamma-H2AX clearance after 5 Gy irradiation in mouse 3T3 fibroblasts relative to vector controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H27c93d908b66" ], "promptChars": 336, "promptSha256": "0600d109a9194c9d7470b0c9a86a3eca6aa4cd95aeed62ec02e8076fc6bc99ea" } ] }, { "task": "H6512044a8ab4", "mapping": [ { "id": "H6512044a8ab4" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H6512044a8ab4] Osteocyte-specific Rankl deletion extends median lifespan of Zmpste24-null progeroid mice compared with Rankl-intact progeroid controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H6512044a8ab4" ], "promptChars": 343, "promptSha256": "73d396ebb9c627b45ff8e3522325a53167ac72147511b2a86bb003a21bb532f4" } ] }, { "task": "H08fabc33f46f", "mapping": [ { "id": "H08fabc33f46f" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H08fabc33f46f] L-carnitine reduces liver metastatic foci after intrasplenic injection of ALDH6A1-deficient AGS gastric cancer cells into nude mice relative to untreated deficient-cell controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H08fabc33f46f" ], "promptChars": 385, "promptSha256": "16c3d5398ddfcb636aedb70864cacd059d1a52cd919fe8dbf478f20210b1369b" } ] }, { "task": "H2a2948ff61da", "mapping": [ { "id": "H2a2948ff61da" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H2a2948ff61da] Vascular-smooth-muscle-cell-specific Mapk14 deletion increases aortic collagen deposition in eighty-six-week-old hyperlipidemic mice relative to age- and sex-matched controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H2a2948ff61da" ], "promptChars": 382, "promptSha256": "1a59be32bdbdffea92b1b11905340b533f62f1c72db1305ecbbc827ce47495ed" } ] }, { "task": "He13f903f3124", "mapping": [ { "id": "He13f903f3124" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[He13f903f3124] Myeloid-specific CK2-alpha deletion extends median lifespan in male mice compared with floxed controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "He13f903f3124" ], "promptChars": 310, "promptSha256": "327264803788e4c552094c2fb82017ae5bc99f784ecf9012cad8deecadbb8709" } ] }, { "task": "H2b4d50ec1df1", "mapping": [ { "id": "H2b4d50ec1df1" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H2b4d50ec1df1] Psme4/PA200 deletion reduces urethane-induced lung tumor counts in middle-aged mice relative to wild-type controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H2b4d50ec1df1" ], "promptChars": 322, "promptSha256": "64c1cf08a98d884e9df238a666cadd05fad1c43148653acc8a40a7bdd0678bcc" } ] }, { "task": "H3c13b7e2d082", "mapping": [ { "id": "H3c13b7e2d082" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H3c13b7e2d082] ORY-1001 at 0.04 mg/kg every other day for eight weeks reduces kidney p16 protein after 7 Gy irradiation in C57BL/6J mice relative to saline.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H3c13b7e2d082" ], "promptChars": 348, "promptSha256": "605c4012f4586c584dfb109d54ed5978e5b6de1ef9654f269d456a31229bb614" } ] }, { "task": "H168dc0d22104", "mapping": [ { "id": "H168dc0d22104" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H168dc0d22104] TRPV4 knockout reduces skin mitochondrial reactive oxygen species after seven days of topical imiquimod in mice compared with imiquimod-treated wild-type controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H168dc0d22104" ], "promptChars": 370, "promptSha256": "e5e4b6ecdd7475ad340d335f5c4602563c97d7b0fd401cb90857c6441174fe9d" } ] }, { "task": "Hb471544edd7b", "mapping": [ { "id": "Hb471544edd7b" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hb471544edd7b] Skeletal-muscle-specific Pla2g6/iPLA2-beta deletion preserves extensor digitorum longus specific force after mouse muscle denervation compared with denervated wild-type controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hb471544edd7b" ], "promptChars": 385, "promptSha256": "e48e2088b09df9b569fe167dabd93cdef376aae569cc7586d00cdbabebce2a86" } ] }, { "task": "H691ed522cf5f", "mapping": [ { "id": "H691ed522cf5f" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H691ed522cf5f] Four days of folate deprivation increases spontaneous interleukin-6 secretion by human HK-2 renal tubular cells compared with folate-replete culture.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H691ed522cf5f" ], "promptChars": 356, "promptSha256": "916500715e43b8ce24aa2853d21a2cf97758f4bb8dd9134d7680af5a2210b696" } ] }, { "task": "H26edd2d7f68a", "mapping": [ { "id": "H26edd2d7f68a" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H26edd2d7f68a] Constitutive skeletal-muscle-specific Crls1 deletion increases lean-mass gain after weaning in mice relative to control littermates.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H26edd2d7f68a" ], "promptChars": 339, "promptSha256": "a0a921863fdcde0a330f8b8279dbe970ac0e03ed3bdedfc15f2d20308207c945" } ] }, { "task": "H16065de616b9", "mapping": [ { "id": "H16065de616b9" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H16065de616b9] FNDC1 knockdown further increases proliferation of ZBED6-deficient primary porcine muscle satellite cells relative to control siRNA in ZBED6-deficient cells.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H16065de616b9" ], "promptChars": 364, "promptSha256": "22f60a16b822204fd2588b57f1a3497ec59749338d4eb1ea5b772a8cfda3b89b" } ] }, { "task": "H2a93004b1bf8", "mapping": [ { "id": "H2a93004b1bf8" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H2a93004b1bf8] Weekly intraperitoneal PDK4-IN at 10 mg/kg for 16 weeks lowers serum ALT in 20-month-old male hepatocyte-specific GHR-knockout mice relative to vehicle.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H2a93004b1bf8" ], "promptChars": 359, "promptSha256": "0d289f6f7787391b94ea158e30f9fcddc15d9624537c4bcc3f477f6d92340fd7" } ] }, { "task": "H4cabb5322f8a", "mapping": [ { "id": "H4cabb5322f8a" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H4cabb5322f8a] Ak050834 deletion further reduces migration of D-galactose-treated primary mouse aortic smooth muscle cells relative to D-galactose-treated wild-type cells.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H4cabb5322f8a" ], "promptChars": 363, "promptSha256": "cc563c896ab6bc7d9f9ae8d8366745cc3e81e9e5d68c41b8eb2dca5366b94f50" } ] }, { "task": "Hd7d86420f325", "mapping": [ { "id": "Hd7d86420f325" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hd7d86420f325] Twenty-eight days of HFI-419 treatment increases kidney hydroxyproline in twenty-eight-month-old mice relative to vehicle-treated aged mice.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hd7d86420f325" ], "promptChars": 347, "promptSha256": "066705524db0adcdcecde76a73e2b55597bcc80581e7b7fcd008a6ff4887fcd2" } ] }, { "task": "Hd792b655ff7a", "mapping": [ { "id": "Hd792b655ff7a" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hd792b655ff7a] Vascular-smooth-muscle-cell-specific Sirt7 deletion reduces abdominal aortic aneurysm rupture in Apoe-null mice receiving four weeks of angiotensin II relative to littermate controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hd792b655ff7a" ], "promptChars": 390, "promptSha256": "970ca6a6b1dbc721b4f02786a96561ce6c004bbff069247a64b58df94db77a07" } ] }, { "task": "Hd34f6a91bf41", "mapping": [ { "id": "Hd34f6a91bf41" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hd34f6a91bf41] Growth hormone given every other day for three weeks lowers testicular gamma-H2AX phosphorylation in aged male mice relative to untreated aged controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hd34f6a91bf41" ], "promptChars": 359, "promptSha256": "efecad54f6c89deaf8ec2e8607a37c1aa559392ea6b1cd525b31c6e66e9c959a" } ] }, { "task": "Hae60cea8ffbf", "mapping": [ { "id": "Hae60cea8ffbf" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hae60cea8ffbf] HBEGF overexpression in Prx1-lineage skeletal progenitors increases cartilage and bone area ten days after femoral fracture in sixteen-month-old mice relative to age-matched wild-type mice.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hae60cea8ffbf" ], "promptChars": 396, "promptSha256": "fc9407de1c83321f92fa4200d12286d18e2fc691b937b617057c4a06ee87af80" } ] }, { "task": "Hed8ca67e265e", "mapping": [ { "id": "Hed8ca67e265e" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hed8ca67e265e] Four weeks of navitoclax treatment improves glucose tolerance in sixteen-week-old mice with pancreatic beta-cell-specific Fmo3 deletion relative to vehicle treatment.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hed8ca67e265e" ], "promptChars": 373, "promptSha256": "fb06b311ac1bf0ad85aff62c50d62c64e7e949555fa15e7c662e79f08ea61f45" } ] }, { "task": "Hcc115f2aa2b3", "mapping": [ { "id": "Hcc115f2aa2b3" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hcc115f2aa2b3] Deleting membrane-bound COMT improves PC12 cell viability after twenty-four hours of 200 micromolar hydrogen peroxide compared with wild-type cells.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hcc115f2aa2b3" ], "promptChars": 355, "promptSha256": "5ed066ce1d4980806a389ba3ef5fe9cb61a359c926fe1dd6ee182ebcdcc3465e" } ] }, { "task": "Hfeee2fca0479", "mapping": [ { "id": "Hfeee2fca0479" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hfeee2fca0479] Dietary coenzyme Q10 increases collagen-induced platelet aggregation in twenty-two-month-old mice relative to age-matched unsupplemented controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hfeee2fca0479" ], "promptChars": 353, "promptSha256": "eda6d230144f64c0d09fe40709db784c549b4de22eefd6c0e39ed10d570177a2" } ] }, { "task": "He6acd9cc7f13", "mapping": [ { "id": "He6acd9cc7f13" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[He6acd9cc7f13] Nanoparticle-delivered Sema3g siRNA reduces hepatic hydroxyproline during carbon-tetrachloride-induced fibrosis in male endothelial-Fbxw7-knockout mice relative to scramble siRNA.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "He6acd9cc7f13" ], "promptChars": 386, "promptSha256": "2f735d3f4ea8da31d32b26fe4ceff417513fafe36d918c62c271b26dcded9fea" } ] }, { "task": "H205c5e7920f5", "mapping": [ { "id": "H205c5e7920f5" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H205c5e7920f5] Vascular-smooth-muscle-cell-specific Mapk14 deletion reduces aortic-arch calcium deposition in eighty-six-week-old hyperlipidemic mice on normal chow relative to age- and sex-matched controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H205c5e7920f5" ], "promptChars": 399, "promptSha256": "da1ecda92ef2afa8ea179ac1dc2533e3540592b15c1deaacefc66fe7451687af" } ] }, { "task": "H1bfb037dac8f", "mapping": [ { "id": "H1bfb037dac8f" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H1bfb037dac8f] GSR inhibition reduces aggregation of lipoylated DLAT during elesclomol-copper treatment in cancer cells relative to treatment without GSR inhibition.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H1bfb037dac8f" ], "promptChars": 357, "promptSha256": "a42640a15903859181d028d8467edd94c918aaa44c16a8ef3380f4a53bf48f56" } ] }, { "task": "H3fc3c2c34cee", "mapping": [ { "id": "H3fc3c2c34cee" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H3fc3c2c34cee] Twenty-four hours of alpha-synuclein treatment increases colocalization of lipid droplets with lysosomes in macrophages relative to untreated macrophages.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H3fc3c2c34cee" ], "promptChars": 361, "promptSha256": "e74454f6ae4bac7be713a46d9dfc445320fbbad807990e3ad3421088e59ca350" } ] }, { "task": "H6b18aea23456", "mapping": [ { "id": "H6b18aea23456" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H6b18aea23456] Sost deletion reduces tibial cortical vascular porosity in seventy-eight-week-old mice compared with littermate controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H6b18aea23456" ], "promptChars": 328, "promptSha256": "0942c2b869cecb3afec68e424c51e8458467f4fe84cb57a422d2aba2e0d5d84f" } ] }, { "task": "H4e43005c4648", "mapping": [ { "id": "H4e43005c4648" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H4e43005c4648] Oxaliplatin combined with anti-PD-1 and anti-ACBP/DBI antibodies prolongs survival of female C57BL/6J mice bearing MCA205 fibrosarcomas with Lmna-sufficient T cells versus vehicle.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H4e43005c4648" ], "promptChars": 387, "promptSha256": "d9db13647fb4c5b1f1d3f6053229f4004394a58a005eb6e7c79eeead8ad01109" } ] }, { "task": "H8925efa06267", "mapping": [ { "id": "H8925efa06267" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H8925efa06267] Myeloid-specific Slc1a5 deletion increases the liver-to-body-weight ratio forty-eight hours after two-thirds hepatectomy in mice relative to littermate controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H8925efa06267" ], "promptChars": 368, "promptSha256": "135cfde93d636054a552e658ea3333fff0b66f600cc51d2715b8ee6e8e115320" } ] }, { "task": "H93c55cfc0f98", "mapping": [ { "id": "H93c55cfc0f98" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H93c55cfc0f98] Enzymatically hydrolyzed eggshell membrane at 4 mg/mL decreases Akt Ser473 phosphorylation in neonatal human epidermal keratinocytes relative to untreated controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H93c55cfc0f98" ], "promptChars": 371, "promptSha256": "9ca6c6e9219d279cec57c8d79bb802ad369998ad648a995a7b77e56d5a167afd" } ] }, { "task": "H685f8b5e8567", "mapping": [ { "id": "H685f8b5e8567" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H685f8b5e8567] AZ3451 pretreatment increases PAR2-agonist-evoked intracellular calcium in human SW982 synoviocytes relative to agonist alone.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H685f8b5e8567" ], "promptChars": 333, "promptSha256": "eafc9b3fa2d1c5fcc614870d04014a00e6d828c90fb744d0664aed41b52594bc" } ] }, { "task": "H0d7baa86124c", "mapping": [ { "id": "H0d7baa86124c" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H0d7baa86124c] Myeloid-specific Rora deletion decreases the proportion of leaky laser-induced choroidal neovascular lesions in eight-month-old mice relative to floxed controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H0d7baa86124c" ], "promptChars": 368, "promptSha256": "e75ca3932c1fd692acd65933828889d4fa3e9c42ead966aa8529a2b43b4bfda2" } ] }, { "task": "H2b4e72ef481d", "mapping": [ { "id": "H2b4e72ef481d" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H2b4e72ef481d] Oxamate inhibition of lactate dehydrogenase increases mitochondrial reactive oxygen species in folate-deficient HK-2 renal tubular cells compared with untreated deficient cells.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H2b4e72ef481d" ], "promptChars": 384, "promptSha256": "7df0639344e3c21366f4f8761a959a561ae497b43876d6cbb7426072175b2d7d" } ] }, { "task": "Heff387c84521", "mapping": [ { "id": "Heff387c84521" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Heff387c84521] Glucagon-receptor-blocking antibody lowers the glucose-tolerance-test area under the curve in aged mice relative to control antibody.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Heff387c84521" ], "promptChars": 340, "promptSha256": "6cc1c7298d0c613245143ffba4d6010ebbcf43da09317dceabfa6324ca678186" } ] }, { "task": "Hc6cc3302a45a", "mapping": [ { "id": "Hc6cc3302a45a" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hc6cc3302a45a] Daily taurine gavage lowers the hepatic phosphorylated-AMPK to total-AMPK ratio in hypothyroid rats relative to water gavage.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hc6cc3302a45a" ], "promptChars": 332, "promptSha256": "fe045d0407382b73c5fc627112babcd7894ab9d8cbe823f770809ef4560d6081" } ] }, { "task": "H282a9ffdd7fd", "mapping": [ { "id": "H282a9ffdd7fd" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H282a9ffdd7fd] Endothelial Fbxw7 deletion reduces hepatic collagen deposition after carbon tetrachloride exposure in male mice relative to control mice.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H282a9ffdd7fd" ], "promptChars": 344, "promptSha256": "503538dcf2583f0888f21e26b716385bb0c90e3cc870ddd589b8d582ae12eb2d" } ] }, { "task": "H2a4cf9bb2c83", "mapping": [ { "id": "H2a4cf9bb2c83" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H2a4cf9bb2c83] Anti-RANKL antibody at 5 mg/kg twice weekly reduces trabecular bone mineral density in Zmpste24-null progeroid mice relative to isotype antibody.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H2a4cf9bb2c83" ], "promptChars": 352, "promptSha256": "7ec5cdb089e6426dd169ff4e308d14d70160ae4deba4ef47df65a70377cf19e0" } ] }, { "task": "H1501b5ea0040", "mapping": [ { "id": "H1501b5ea0040" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H1501b5ea0040] Ak050834 deletion reduces vascular beta-galactosidase staining in naturally aged mice relative to wild-type aged mice.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H1501b5ea0040" ], "promptChars": 325, "promptSha256": "f0440754d24e23436d17b8540a59ff8782e363530ad0d34c7b7596747d61e398" } ] }, { "task": "Hf7ad0950ca22", "mapping": [ { "id": "Hf7ad0950ca22" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hf7ad0950ca22] pyr-1 RNA interference extends Caenorhabditis elegans lifespan under normal culture conditions relative to empty-vector RNA interference.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hf7ad0950ca22" ], "promptChars": 344, "promptSha256": "3d8ff721181a69d224d668cc0440ac6ee72d9aee50de69ddafd215385a627862" } ] }, { "task": "Hfbd997710a91", "mapping": [ { "id": "Hfbd997710a91" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hfbd997710a91] The GSK3-beta inhibitor SB216763 reduces lung fibrosis in mice with conditional beta-PIX deletion in alveolar type-II cells relative to vehicle treatment.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hfbd997710a91" ], "promptChars": 361, "promptSha256": "117b2a8defb60c7601df4211217ff942f96d3f4d4f233692c7946a1f998315af" } ] }, { "task": "H54e4307dd731", "mapping": [ { "id": "H54e4307dd731" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H54e4307dd731] Dietary citrulline at 10 mM extends Caenorhabditis elegans median survival under normal culture conditions relative to unsupplemented controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H54e4307dd731" ], "promptChars": 350, "promptSha256": "7ac0a3f163f625240f1e30ef9e51bfe255b8f635a1a2745c4d757dd5b530aa20" } ] }, { "task": "Hcac20bec2aa2", "mapping": [ { "id": "Hcac20bec2aa2" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hcac20bec2aa2] Endothelial-specific Piezo1 deletion reduces hippocampal sodium-fluorescein leakage after anesthesia and surgery in mice relative to Piezo1-intact controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hcac20bec2aa2" ], "promptChars": 363, "promptSha256": "60a47edde74e002ea00436b748ef3581274435044583d50715449b49cf3b4a86" } ] }, { "task": "H076a42491f62", "mapping": [ { "id": "H076a42491f62" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H076a42491f62] Intra-articular AAV-driven constitutive ERK5 activation lowers knee cartilage OARSI scores eight weeks after meniscal destabilization in adult mice relative to control AAV.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H076a42491f62" ], "promptChars": 379, "promptSha256": "6198aea3a8f040673c3db1fca1d244477eff7d5c09b784a5456a46ca3ff3e31c" } ] }, { "task": "H87388412c2a6", "mapping": [ { "id": "H87388412c2a6" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H87388412c2a6] Hepatocyte-specific Nos3/eNOS deletion reduces serum ALT activity after two weeks of carbon-tetrachloride challenge in mice compared with floxed controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H87388412c2a6" ], "promptChars": 361, "promptSha256": "09196085a03795fa385dcd0a94f09966c8bf41d9c4177efd86c1fc9dcdd902d5" } ] }, { "task": "Hbe6b696a434f", "mapping": [ { "id": "Hbe6b696a434f" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hbe6b696a434f] Muscle-specific Pla2g6/iPLA2-beta deletion further reduces depolarization-evoked force in denervated mouse fast-twitch fibers compared with denervated wild-type fibers.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hbe6b696a434f" ], "promptChars": 375, "promptSha256": "b04ea5b6b1b1e06653963a8a01fbeb057f11f7bbb3519f41db64572afc2d4230" } ] }, { "task": "H7f9a0c89b5f6", "mapping": [ { "id": "H7f9a0c89b5f6" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H7f9a0c89b5f6] The PPAR-gamma antagonist T0070907 reduces laser-induced choroidal neovascular lesion size in two-to-three-month-old myeloid-specific Rora-knockout mice compared with vehicle.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H7f9a0c89b5f6" ], "promptChars": 382, "promptSha256": "28b074a56d586555f46f8af930d8691630843d8618c00ac5d433e8048f61f55a" } ] }, { "task": "H0e9581097799", "mapping": [ { "id": "H0e9581097799" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H0e9581097799] Hepatocyte-specific Sirt6 deletion increases hepatic Sult1e1 gene expression in aged female mice relative to floxed controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H0e9581097799" ], "promptChars": 332, "promptSha256": "95cc46ce82d08eb1e90f9eb8c28f9e6e273dbb1015d70beb7c77462271393dfc" } ] }, { "task": "Hb3e6742eec1d", "mapping": [ { "id": "Hb3e6742eec1d" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hb3e6742eec1d] SDF-1 at 10 micrograms/kg intraperitoneally for fourteen days increases pups per litter in aged female mice relative to saline-treated aged controls.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hb3e6742eec1d" ], "promptChars": 356, "promptSha256": "3fd3d061270223dd4e7b28a8e81386c1697e639479eda2b17ba08b86f6b26ddb" } ] }, { "task": "Hb1e07c55f832", "mapping": [ { "id": "Hb1e07c55f832" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hb1e07c55f832] Skeletal-muscle-specific Crls1 deletion decreases the proportion of type IIb fibers in mouse extensor digitorum longus compared with control littermates.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hb1e07c55f832" ], "promptChars": 360, "promptSha256": "1941c4e4279a02bcf4279297f7b00d492150cd479876e15c707b3c4f0fa3eef4" } ] }, { "task": "H583619d01105", "mapping": [ { "id": "H583619d01105" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H583619d01105] Re-expression of wild-type human GSR restores resistance to RSL3-induced ferroptosis in Gsr-knockout mouse 4T1 breast cancer cells relative to empty-vector knockout cells.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H583619d01105" ], "promptChars": 378, "promptSha256": "8a5983723e6c6a2cbdd1c375c3a8b2b384c95ba62e443615b7a8759e9fb881bd" } ] }, { "task": "H7b9b93427c7e", "mapping": [ { "id": "H7b9b93427c7e" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H7b9b93427c7e] Dietary pterostilbene at 100 mg per kg of diet reduces weight gain during thirteen weeks of high-fat feeding in male mice relative to high-fat diet alone.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H7b9b93427c7e" ], "promptChars": 361, "promptSha256": "e5f8445327e4fde9506626009c9cca26327a47e682511e419c67e806c9df422c" } ] }, { "task": "Hc2e66a4b720a", "mapping": [ { "id": "Hc2e66a4b720a" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[Hc2e66a4b720a] Nicotinamide mononucleotide supplementation reduces abdominal aortic aneurysm incidence in angiotensin-II-infused Apoe-null mice relative to saline.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "Hc2e66a4b720a" ], "promptChars": 355, "promptSha256": "1f82ce6ca015ac9621fb33d9027e3273476ffb72f31ba6b459ace2529bc14fc2" } ] }, { "task": "H4dc9b9da3a06", "mapping": [ { "id": "H4dc9b9da3a06" } ], "requests": [ { "protocol": "balanced-confirmation-v1", "system": "Return a JSON object.", "user": "Will this hypothesis be confirmed experimentally?\n\nHYPOTHESIS\n[H4dc9b9da3a06] Chronic diosmin supplementation improves acetylcholine-induced vascular relaxation in aged rats relative to vehicle-treated aged rats.\n\nReturn a JSON object with a \"forecasts\" array containing this hypothesis's \"id\" and a boolean \"confirmed\".", "candidateIds": [ "H4dc9b9da3a06" ], "promptChars": 341, "promptSha256": "21a9f0cc1e56f163452b69ea69e276121a70b423797b7e049ec2680f0dda2d81" } ] } ] }