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самцов мышей относительно обычных мышей из того же помёта.", "observed": "Concentration fell from 34.94 to 17.94 million/mL, P = 0.0057.", "observedRu": "Концентрация снизилась с 34,94 до 17,94 млн/мл, P = 0,0057.", "figure": "Supplementary Figure 5F", "paragraph": "p55", "quote": "17.94 ± 8.18 million/mL vs. 34.94 ± 12.26 million/mL, P = 0.0057", "id": "H556eb44d6587", "sourceId": "B42458466", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "The STING inhibitor H-151 at 25 mg/L in drinking water extends male Lmna-G609G progeroid mouse median lifespan relative to vehicle.", "ru": "Ингибитор STING H-151 в питьевой воде в концентрации 25 мг/л увеличивает медианную продолжительность жизни самцов мышей с прогерией Lmna-G609G относительно растворителя.", "observed": "Male median survival increased from 122 to 149 days; log-rank p<0.001.", "observedRu": "Медианная выживаемость самцов выросла со 122 до 149 дней; логранговый критерий дал P < 0,001.", "figure": "Figure 5g", "paragraph": "p15", "quote": "extended from 122 days in vehicle-treated mice to 149 days", "id": "Hf84dc04d9967", "sourceId": "B42749730", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Hepatocyte-specific GHR deletion extends male mouse lifespan relative to floxed littermate controls.", "ru": "Удаление GHR только в гепатоцитах увеличивает продолжительность жизни самцов мышей относительно контрольных животных того же помёта.", "observed": "Male hepatocyte-specific GHR-knockout mice had shorter survival; controls n=27, knockout n=20.", "observedRu": "Самцы с удалённым GHR в гепатоцитах жили меньше; контрольная группа включала 27 мышей, опытная 20.", "figure": "Figure 1B", "paragraph": "p28", "quote": "Male LiGHR−/− mice exhibited a shortened lifespan", "id": "Hd366df6c0c2d", "sourceId": "B42791620", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Twelve weeks of dietary coenzyme Q10 increases bone-marrow megakaryocyte colony counts in twelve-month-old mice relative to unsupplemented controls.", "ru": "Двенадцать недель добавления коэнзима Q10 к рациону увеличивают число колоний мегакариоцитов костного мозга у двенадцатимесячных мышей относительно рациона без добавки.", "observed": "Megakaryocyte colony counts increased at twelve months; p<0.05.", "observedRu": "В двенадцатимесячном возрасте число колоний мегакариоцитов выросло; P < 0,05.", "figure": "Figure 2A,B", "paragraph": "p7", "quote": "significantly increased colony counts", "id": "Hca5687df1d17", "sourceId": "B42808563", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Co-culture with sardomozide-pretreated fibro-adipogenic progenitors increases nuclei per myotube during mouse muscle stem cell differentiation relative to untreated-progenitor co-culture.", "ru": "Совместное культивирование мышечных стволовых клеток мыши с клетками-предшественниками фибробластов и жировых клеток, предварительно обработанными сардомозидом, увеличивает число ядер в образующихся мышечных трубочках по сравнению с совместным культивированием с необработанными клетками-предшественниками.", "observed": "Nuclei per myotube decreased.", "observedRu": "Число ядер в мышечной трубочке снизилось.", "figure": "Supplementary Figure 5G-J", "paragraph": "p59", "quote": "a reduced average number of nuclei per myotube", "id": "H00754d90403e", "sourceId": "B42602328", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Dasatinib plus quercetin increases mineralized callus bone volume twenty-eight days after fracture in mice lacking Cbfb in Adipoq-positive marrow cells relative to untreated knockout mice.", "ru": "Дазатиниб с кверцетином увеличивают объём минерализованной костной мозоли через 28 дней после перелома у мышей с удалённым Cbfb в Adipoq-положительных клетках костного мозга относительно таких же мышей без лечения.", "observed": "Treatment increased mineralized callus volume.", "observedRu": "Лечение увеличило объём минерализованной костной мозоли.", "figure": "Supplementary Figure 14k-n", "paragraph": "p38", "quote": "increased callus formation and mineralized bone volume", "id": "H7b5933386c64", "sourceId": "B42575886", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "ALDH6A1 overexpression increases Transwell migration of human AGS gastric cancer cells relative to vector controls.", "ru": "Повышение экспрессии ALDH6A1 усиливает миграцию человеческих клеток рака желудка AGS через мембрану Transwell относительно контрольного вектора.", "observed": "Overexpression inhibited migration.", "observedRu": "Повышение экспрессии подавило миграцию.", "figure": "Figure 2A-C", "paragraph": "p9", "quote": "overexpression of ALDH6A1 inhibited these abilities", "id": "H9cb69403e6d8", "sourceId": "B42418576", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Grtp1 deletion increases the percentage of progressively motile sperm in three-to-four-month-old male mice compared with age-matched wild-type controls.", "ru": "Удаление Grtp1 увеличивает долю поступательно подвижных сперматозоидов у трёх-четырёхмесячных самцов мышей относительно обычных животных того же возраста.", "observed": "Progressively motile sperm decreased from 62% in young controls to 27% after knockout.", "observedRu": "Доля поступательно подвижных сперматозоидов снизилась с 62% у молодых контрольных мышей до 27% после удаления гена.", "figure": "Figure 2D", "paragraph": "p11", "quote": "27% in the Grtp1‐KO group", "id": "H3d94392f96ae", "sourceId": "B42801556", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Induced NICD expression prevents depletion of Pax7-positive muscle stem cells in Kmt5a-deficient adult mice twenty-one days after muscle injury.", "ru": "Принудительная экспрессия внутриклеточного домена Notch (NICD) предотвращает истощение пула мышечных стволовых клеток с Pax7 у взрослых мышей с удалённым Kmt5a через 21 день после повреждения мышцы.", "observed": "Despite NICD, the injured knockout muscle showed near-complete stem-cell depletion at day 21.", "observedRu": "При экспрессии NICD пул стволовых клеток в повреждённой мышце без Kmt5a оставался почти полностью истощённым на 21-й день.", "figure": "Supplementary Figure S1D", "paragraph": "p25", "quote": "near-complete depletion of the MuSC pool", "id": "H591cc6bdd061", "sourceId": "B42733840", "adjudication": "direct_failed_postinjury_rescue" }, { "confirmed": false, "en": "Deleting guanylyl-cyclase-A receptors in adrenal zona-glomerulosa cells reduces the blood-pressure increase induced by two weeks of 4% dietary salt in mice.", "ru": "Удаление рецептора GC-A (гуанилатциклазы A) в клетках клубочковой зоны надпочечников уменьшает рост артериального давления после двух недель питания с 4% соли у мышей.", "observed": "The pressure increase was 8.2 mmHg in knockout mice versus 4.6 mmHg in controls.", "observedRu": "После удаления рецептора давление выросло на 8,2 мм рт. ст. против 4,6 мм рт. ст. в контроле.", "figure": "Figure 3A", "paragraph": "p27", "quote": "4.6 mm Hg in control and by 8.2 mm Hg in KO", "id": "H699141a0e533", "sourceId": "B42717871", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Hepatocyte-specific Sirt6 deletion lowers hepatic Cdkn1a expression in aged female mice relative to floxed controls.", "ru": "Удаление Sirt6 в гепатоцитах снижает экспрессию Cdkn1a в печени старых самок мышей относительно контроля с сохранённым геном.", "observed": "Cdkn1a increased 4.24-fold, P < 0.05.", "observedRu": "Экспрессия Cdkn1a выросла в 4,24 раза, P < 0,05.", "figure": "Figure 6F", "paragraph": "p19", "quote": "Cdkn1a (p21, +4.24-fold)", "id": "H2a068a10286e", "sourceId": "B42589691", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Fgf21 knockout lowers uterine interleukin-1 beta protein after intrauterine lipopolysaccharide challenge in mice relative to challenged wild-type controls.", "ru": "Удаление Fgf21 снижает содержание интерлейкина-1β в матке мышей после внутриматочного липополисахарида относительно обычных мышей с тем же воздействием.", "observed": "Knockout increased uterine interleukin-1 beta protein after lipopolysaccharide.", "observedRu": "После удаления Fgf21 содержание интерлейкина-1β в матке при воспалении повысилось.", "figure": "Figure 2L", "paragraph": "p26", "quote": "increased protein levels of TNF-α and IL-1β", "id": "H5ae76ff04768", "sourceId": "B42479094", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Inducible cartilage-specific Erk5 deletion lowers knee cartilage OARSI damage scores after destabilization of the medial meniscus in adult mice relative to controls.", "ru": "Индуцируемое удаление Erk5 в хряще взрослых мышей снижает балл повреждения коленного хряща OARSI после дестабилизации медиального мениска относительно контроля.", "observed": "Cartilage Erk5 knockout reduced OARSI histological damage scores after surgery.", "observedRu": "Удаление Erk5 в хряще снизило гистологический балл повреждения после операции.", "figure": "Figure 2b,c", "paragraph": "p6", "quote": "OARSI scores were lower in CKO mice", "id": "H9cc800ed9167", "sourceId": "B42686685", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Whole-body Ghr ablation initiated at twelve months increases male mouse body weight at nineteen months relative to controls.", "ru": "Удаление Ghr во всём организме, начатое в 12 месяцев, повышает массу тела самцов мышей в возрасте 19 месяцев относительно контроля.", "observed": "Male body weight decreased at nineteen and twenty-three months, P < 0.0001.", "observedRu": "Масса тела самцов снизилась в 19 и 23 месяца, P < 0,0001.", "figure": "Figure 1g", "paragraph": "p7", "quote": "reduced in 12mGHRKO males", "id": "Hc35db8c00454", "sourceId": "B42698366", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Cbfb deletion in Adipoq-positive marrow cells increases PDGFR-alpha-positive skeletal progenitor abundance in mice relative to control mice.", "ru": "Удаление Cbfb в Adipoq-положительных клетках костного мозга увеличивает число скелетных клеток-предшественников с PDGFR-альфа у мышей относительно контроля.", "observed": "PDGFR-alpha-positive progenitors were significantly reduced.", "observedRu": "Число клеток-предшественников с PDGFR-альфа достоверно снизилось.", "figure": "Supplementary Figure 14o-v", "paragraph": "p39", "quote": "were significantly reduced in Cbfβ CKO mice", "id": "Hb19a1eaedf6f", "sourceId": "B42575886", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Adding chloroquine to SDF-1-treated aged mouse oocytes decreases G3BP1 fluorescence relative to SDF-1 alone.", "ru": "Добавление хлорохина к SDF-1 в ооцитах старых мышей снижает флуоресценцию G3BP1 относительно одного SDF-1.", "observed": "Chloroquine increased G3BP1 and blocked SDF-1-associated stress-granule clearance.", "observedRu": "Хлорохин повысил сигнал G3BP1 и заблокировал удаление стрессовых гранул при действии SDF-1.", "figure": "Figure 8E,F", "paragraph": "p20", "quote": "CQ supplementary enhanced the expression of G3BP1", "id": "Ha6af01b29947", "sourceId": "B42544868", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Adding L-glutamine restores apoptotic-cell engulfment by Slc1a5-deficient mouse bone-marrow-derived macrophages relative to unsupplemented deficient macrophages.", "ru": "Добавление L-глутамина восстанавливает поглощение погибающих клеток макрофагами из костного мозга мышей с удалённым Slc1a5 по сравнению с такими же макрофагами без добавки.", "observed": "L-glutamine significantly restored efferocytosis.", "observedRu": "L-глутамин достоверно восстановил поглощение погибающих клеток.", "figure": "Figure 6f,g", "paragraph": "p19", "quote": "significantly restored the efferocytosis function", "id": "H2d91f2d3ca48", "sourceId": "B42678502", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Sardomozide inhibition of AMD1 increases Cdkn1a expression in fibro-adipogenic progenitors isolated from young mouse skeletal muscle relative to untreated progenitors.", "ru": "Ингибирование AMD1 сардомозидом повышает экспрессию Cdkn1a в клетках-предшественниках фибробластов и жировых клеток, выделенных из скелетных мышц молодых мышей, по сравнению с клетками без воздействия.", "observed": "Cdkn1a increased, P < 0.0001.", "observedRu": "Экспрессия Cdkn1a выросла, P < 0,0001.", "figure": "Figure 5C", "paragraph": "p47", "quote": "an early induction of the cell cycle inhibitor Cdkn1a", "id": "Hbb8d36395a4f", "sourceId": "B42602328", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Induced NICD expression preserves the quiescent Pax7-positive muscle stem-cell pool in Kmt5a-deficient adult mice six weeks after tamoxifen under homeostasis.", "ru": "Принудительная экспрессия внутриклеточного домена Notch (NICD) сохраняет пул покоящихся мышечных стволовых клеток с Pax7 у взрослых мышей с удалённым Kmt5a через шесть недель после введения тамоксифена в отсутствие травмы.", "observed": "NICD prevented stem-cell depletion and reduced Ki67-positive activation under homeostasis.", "observedRu": "NICD предотвратил истощение пула стволовых клеток и уменьшил их активацию по маркеру Ki67 в отсутствие травмы.", "figure": "Figure 2B-D", "paragraph": "p24", "quote": "prevented depletion of the Pax7+ stem cell pool", "id": "Hdc04751acc25", "sourceId": "B42733840", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Taurine supplementation lowers serum LDL cholesterol in hypothyroid rats relative to hypothyroid rats receiving water alone.", "ru": "Добавление таурина снижает содержание холестерина липопротеинов низкой плотности в сыворотке крыс с гипотиреозом относительно крыс с гипотиреозом, получающих только воду.", "observed": "Elevated LDL cholesterol decreased after taurine.", "observedRu": "Повышенное содержание холестерина липопротеинов низкой плотности снизилось после таурина.", "figure": "Figure 3C", "paragraph": "p21", "quote": "were reduced following taurine supplementation", "id": "H0b95ea5bca8b", "sourceId": "B42485573", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "T-cell-specific Lmna deletion improves female MCA205 tumor-bearing mouse survival during combined oxaliplatin, anti-PD-1 and anti-ACBP/DBI treatment compared with T-cell-Lmna-sufficient controls.", "ru": "Удаление Lmna в T-клетках повышает выживаемость самок мышей с опухолью MCA205 при сочетании оксалиплатина с антителами к PD-1 и ACBP/DBI по сравнению с животными с сохранённым геном.", "observed": "T-cell Lmna loss worsened treatment survival; female genotype comparison p=0.0047.", "observedRu": "Удаление Lmna в T-клетках ухудшило выживаемость при лечении; сравнение генотипов у самок дало P = 0,0047.", "figure": "Figure 1C; Figure 3B", "paragraph": "p14", "quote": "p=0.0047 in females", "id": "Hc51c63819170", "sourceId": "B42774966", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Seven days of 20 micromolar XL20 reduces dendritic spine density in human induced-pluripotent-stem-cell-derived motor neurons with TDP43-Q331K relative to vehicle-treated mutant neurons.", "ru": "Воздействие 20 мкМ XL20 в течение семи дней снижает плотность дендритных шипиков в человеческих двигательных нейронах, полученных из индуцированных плюрипотентных стволовых клеток с TDP43-Q331K, относительно мутантных нейронов с растворителем.", "observed": "XL20 restored spine density toward isogenic-control levels.", "observedRu": "XL20 восстановил плотность шипиков до уровня генетически сопоставимого контроля.", "figure": "Figure 4k", "paragraph": "p13", "quote": "restoring spine density and cytoplasmic TDP-43 levels", "id": "Hbcb2664c171e", "sourceId": "B42399370", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Snca deletion reduces whole-aorta atherosclerotic lesion area in male mice after AAV-PCSK9 administration and sixteen weeks of high-cholesterol feeding relative to wild-type littermates.", "ru": "Удаление Snca уменьшает площадь атеросклеротических поражений всей аорты у самцов мышей после введения AAV-PCSK9 и 16 недель питания с высоким содержанием холестерина относительно обычных мышей из того же помёта.", "observed": "Whole-aorta and aortic-arch lesion areas were significantly smaller.", "observedRu": "Площадь поражений всей аорты и её дуги достоверно уменьшилась.", "figure": "Figure 1c-e", "paragraph": "p8", "quote": "significantly smaller lesion areas", "id": "Hd41fa6090167", "sourceId": "B42806619", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Enzymatically hydrolyzed eggshell membrane increases KRT1 expression in cultured neonatal human epidermal keratinocytes compared with untreated cells.", "ru": "Ферментативный гидролизат подскорлупной оболочки повышает экспрессию KRT1 в культуре эпидермальных кератиноцитов новорождённого человека относительно клеток без обработки.", "observed": "Hydrolyzed membrane dose-dependently increased KRT1 and other differentiation markers.", "observedRu": "Гидролизат дозозависимо повысил KRT1 и другие маркеры дифференцировки.", "figure": "Figure 1B", "paragraph": "p17", "quote": "significantly upregulated the expression of KRT1", "id": "H108fec88412d", "sourceId": "B42644214", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Pdha1 silencing decreases lactate production in D-galactose-treated primary mouse pulmonary endothelial cells relative to control silencing.", "ru": "Подавление Pdha1 снижает образование лактата в первичных лёгочных эндотелиальных клетках мыши при воздействии D-галактозы относительно контрольного подавления.", "observed": "Pdha1 silencing increased lactate production under D-galactose.", "observedRu": "Подавление Pdha1 увеличило образование лактата при воздействии D-галактозы.", "figure": "Figure 5G", "paragraph": "p13", "quote": "increased D-gal-induced lactate production", "id": "H5401e2f1476e", "sourceId": "B42625807", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Sost deletion increases tibial cortical thickness in seventy-eight-week-old mice relative to littermate controls.", "ru": "Удаление Sost увеличивает толщину кортикального слоя большеберцовой кости у мышей в возрасте семидесяти восьми недель относительно контрольных животных того же помёта.", "observed": "Cortical thickness was 246% greater in seventy-eight-week-old knockout mice.", "observedRu": "Толщина кортикального слоя у мышей с удалённым геном была выше на 246%.", "figure": "Figure 2B; Table 2", "paragraph": "p26", "quote": "Ct.Th (246%)", "id": "H8856cfb6fb8c", "sourceId": "B42502704", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Recombinant human FGF21 administered before intrauterine lipopolysaccharide lowers uterine histopathological injury scores in mice compared with lipopolysaccharide alone.", "ru": "Введение рекомбинантного человеческого FGF21 перед внутриматочным липополисахаридом снижает гистологический балл повреждения матки у мышей относительно введения одного липополисахарида.", "observed": "FGF21 pretreatment significantly reduced histopathological injury scores.", "observedRu": "Предварительное введение FGF21 снизило гистологический балл повреждения матки.", "figure": "Figure 3C,D", "paragraph": "p28", "quote": "a significant decrease in histopathological scores", "id": "H7d64d0c884ee", "sourceId": "B42479094", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "FNDC1 overexpression restores EdU-labelled proliferation in ZBED6-overexpressing primary porcine muscle satellite cells relative to ZBED6 overexpression alone.", "ru": "Повышение экспрессии FNDC1 восстанавливает деление первичных сателлитных клеток мышц свиньи с повышенной экспрессией ZBED6 по включению EdU относительно одного повышения ZBED6.", "observed": "FNDC1 increased the number of EdU-positive cells in the ZBED6-overexpressing background.", "observedRu": "На фоне повышенной экспрессии ZBED6 белок FNDC1 увеличил число клеток, включивших EdU.", "figure": "Figure 4A,B", "paragraph": "p32", "quote": "significantly increased the number of EdU-positive cells", "id": "Hd2867abf0b74", "sourceId": "B42830286", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Conditional beta-PIX deletion in alveolar type-II cells increases the alveolar type-I to type-II cell ratio four weeks after induction in mice relative to wild-type controls.", "ru": "Условное удаление бета-PIX в альвеолярных клетках второго типа повышает отношение альвеолярных клеток первого типа ко второму через четыре недели после индукции у мышей относительно обычного контроля.", "observed": "The ratio decreased by 40%.", "observedRu": "Отношение снизилось на 40%.", "figure": "Supplementary Figure 11", "paragraph": "p20", "quote": "a significant decrease of 40%", "id": "Hde2c7f764541", "sourceId": "B42716949", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Psme4/PA200 deletion increases lung p53 protein in middle-aged mice subjected to urethane-induced tumorigenesis compared with wild-type controls.", "ru": "Удаление Psme4/PA200 повышает содержание p53 в лёгких мышей среднего возраста при вызванном уретаном опухолеобразовании относительно обычных контрольных мышей.", "observed": "Lung p53 was lower, not higher, in PA200-deficient middle-aged mice.", "observedRu": "Содержание p53 в лёгких мышей среднего возраста после удаления PA200 снизилось.", "figure": "Figure 6j", "paragraph": "p22", "quote": "p53 levels were lower in PA200 KO mice", "id": "Hb84019cbdccd", "sourceId": "B42884025", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Endothelial-specific Pdha1 deletion lowers pulmonary endothelial p21 expression in D-galactose-treated mice compared with treated control littermates.", "ru": "Удаление Pdha1 в эндотелии снижает содержание p21 в лёгочном эндотелии мышей, получающих D-галактозу, относительно контрольных животных с тем же воздействием.", "observed": "Endothelial Pdha1 deletion reduced lung endothelial p21 staining after D-galactose.", "observedRu": "Удаление Pdha1 уменьшило окрашивание на p21 в лёгочном эндотелии после D-галактозы.", "figure": "Figure 4A,B", "paragraph": "p11", "quote": "decreased endothelial (CD31+) senescence-related molecule p21 expression", "id": "Hd06b5abc8c17", "sourceId": "B42625807", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Intra-articular PAMAM-Chol-AZ3451 nanoparticles reduce mechanical allodynia twenty-four hours after treatment in mice with monoiodoacetate-induced knee osteoarthritis relative to vehicle.", "ru": "Внутрисуставное введение наночастиц PAMAM-Chol-AZ3451 уменьшает механическую аллодинию через сутки у мышей с вызванным монойодацетатом остеоартритом колена относительно растворителя.", "observed": "Drug-loaded nanoparticles produced sustained anti-allodynic effects peaking at twenty-four hours.", "observedRu": "Наночастицы с препаратом устойчиво уменьшили аллодинию с максимумом эффекта через сутки.", "figure": "Figure 1B-D", "paragraph": "p22", "quote": "a profound and prolonged reduction", "id": "Ha8f158ded9d3", "sourceId": "B42726576", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Renal-tubule-specific Erbin deletion reduces serum creatinine one day after kidney ischemia-reperfusion in mice relative to control littermates.", "ru": "Удаление Erbin в почечных канальцах снижает сывороточный креатинин у мышей через сутки после ишемии-реперфузии почки относительно контрольных животных того же помёта.", "observed": "Tubular Erbin knockout increased serum creatinine after injury; five mice per group.", "observedRu": "После удаления Erbin в канальцах сывороточный креатинин при повреждении вырос; по пять мышей в группе.", "figure": "Figure 2C", "paragraph": "p12", "quote": "were significantly augmented in Erbin-KO mice", "id": "H6e57c7188991", "sourceId": "B42637932", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "TRPV4 knockout increases the phosphorylated-Akt to total-Akt ratio in mouse skin after seven days of topical imiquimod relative to treated wild-type controls.", "ru": "Удаление TRPV4 увеличивает отношение фосфорилированного Akt к общему Akt в коже мышей после семи дней нанесения имиквимода относительно обычных мышей с тем же воздействием.", "observed": "TRPV4 deletion reduced imiquimod-induced Akt phosphorylation.", "observedRu": "Удаление TRPV4 уменьшило вызванное имиквимодом фосфорилирование Akt.", "figure": "Figure 1C,D", "paragraph": "p19", "quote": "TRPV4 deletion markedly attenuated IMQ-induced Akt phosphorylation", "id": "H69deb1edcdbe", "sourceId": "B42782838", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Adenoviral Erbin overexpression in kidney cortex before ischemia-reperfusion reduces renal interstitial collagen deposition fourteen days after injury relative to control adenovirus in mice.", "ru": "Усиление экспрессии Erbin аденовирусом в коре почки перед ишемией-реперфузией снижает межуточное отложение коллагена через четырнадцать дней после повреждения у мышей относительно контрольного аденовируса.", "observed": "Erbin overexpression reduced post-injury interstitial collagen; five mice per group.", "observedRu": "Усиление экспрессии Erbin снизило межуточное отложение коллагена после повреждения; по пять мышей в группе.", "figure": "Figure 3G,H", "paragraph": "p15", "quote": "reduced collagen deposition in renal interstitium", "id": "H770b494c23de", "sourceId": "B42637932", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Deleting membrane-bound COMT increases basal CellROX oxidative-stress signal in rat PC12 cells relative to wild-type cells.", "ru": "Удаление мембранной COMT повышает исходный сигнал окислительного стресса CellROX в клетках крысы PC12 относительно обычных клеток.", "observed": "COMT-deficient cells had higher basal oxidative stress by CellROX.", "observedRu": "В клетках без COMT исходный окислительный стресс по CellROX был выше.", "figure": "Figure 1D,E", "paragraph": "p9", "quote": "oxidative stress levels were markedly higher", "id": "Ha24c224c2c5c", "sourceId": "B42748150", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Two weeks of alternate-day fasting before carbon-tetrachloride challenge reduces subsequent mouse liver fibrosis relative to freely fed controls.", "ru": "Две недели голодания через день перед воздействием четырёххлористого углерода уменьшают последующий фиброз печени у мышей относительно свободного питания.", "observed": "Fasting preconditioning reduced Sirius-Red-defined fibrosis after carbon tetrachloride.", "observedRu": "После голодания фиброз при воздействии четырёххлористого углерода уменьшился по окрашиванию Sirius Red.", "figure": "Figure 5C", "paragraph": "p12", "quote": "reduced fibrotic pathology", "id": "H312a9208a0df", "sourceId": "B42801580", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Beta-cell-specific Fmo3 deletion improves glucose tolerance in twelve-week-old mice relative to wild-type littermates.", "ru": "Удаление Fmo3 в бета-клетках улучшает переносимость глюкозы у 12-недельных мышей относительно обычных мышей из того же помёта.", "observed": "Knockout mice developed glucose intolerance starting at twelve weeks.", "observedRu": "С 12-недельного возраста у мышей с удалённым геном появилась нарушенная переносимость глюкозы.", "figure": "Figure 2e,f", "paragraph": "p10", "quote": "starting at 12 weeks of age", "id": "Hdd257b1a803d", "sourceId": "B42649194", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Nox4 overexpression in brain endothelial cells further reduces hippocampal sodium-fluorescein leakage after anesthesia and surgery in endothelial-Piezo1-knockout mice relative to control virus.", "ru": "Повышение экспрессии Nox4 в эндотелиальных клетках мозга дополнительно уменьшает утечку флуоресцеина натрия в гиппокамп после наркоза и операции у мышей с удалённым Piezo1 в эндотелии относительно контрольного вируса.", "observed": "Nox4 overexpression exacerbated leakage and abolished the protective effect of Piezo1 deletion.", "observedRu": "Повышение экспрессии Nox4 усилило утечку и устранило защитное действие удаления Piezo1.", "figure": "Figure 7N,O", "paragraph": "p17", "quote": "was significantly exacerbated", "id": "H5a66cc1d176d", "sourceId": "B42591729", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Prx1-lineage Egfr deletion increases the fracture-callus bone-volume fraction at twenty-eight days after femoral fracture in mice relative to wild-type controls.", "ru": "Удаление Egfr в клетках линии Prx1 повышает долю костной ткани в костной мозоли через 28 дней после перелома бедренной кости у мышей относительно обычных контрольных мышей.", "observed": "Bone-volume fraction was significantly reduced at both twenty-eight and forty-two days.", "observedRu": "Доля костной ткани достоверно снизилась на 28-й и 42-й день.", "figure": "Figure 2B", "paragraph": "p9", "quote": "BV/TV was significantly reduced", "id": "Hf40c85e4b441", "sourceId": "B42598518", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "PAPPA overexpression reduces apoptosis caused by miR-27b-3p mimics in KGN granulosa cells exposed to 4-vinylcyclohexene diepoxide relative to empty vector.", "ru": "Повышение экспрессии PAPPA уменьшает апоптоз, вызванный имитаторами miR-27b-3p в гранулёзных клетках KGN при воздействии диэпоксида 4-винилциклогексена, по сравнению с пустым вектором.", "observed": "PAPPA co-expression reversed the pro-apoptotic phenotype; p<0.001.", "observedRu": "Совместная экспрессия PAPPA уменьшила апоптоз; P < 0,001.", "figure": "Figure 4C,D", "paragraph": "p17", "quote": "reversed both the proliferation blockade and pro-apoptotic phenotype", "id": "H2bf61d6a2dae", "sourceId": "B42650159", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "miR-27b-3p mimic transfection increases secreted IGF-1 in 4-vinylcyclohexene-diepoxide-injured KGN granulosa cells relative to scrambled controls.", "ru": "Введение имитаторов miR-27b-3p повышает секрецию IGF-1 гранулёзными клетками KGN, повреждёнными диэпоксидом 4-винилциклогексена, относительно контрольной последовательности.", "observed": "miR-27b-3p overexpression reduced secreted IGF-1; p<0.001.", "observedRu": "Усиление miR-27b-3p снизило секрецию IGF-1; P < 0,001.", "figure": "Figure 5C", "paragraph": "p18", "quote": "drastically reduced IGF-1 secretion", "id": "H69d1974ef6f3", "sourceId": "B42650159", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Twenty-four-hour atrial natriuretic peptide pretreatment attenuates angiotensin-II-induced ERK phosphorylation in human H295R adrenal cells compared with angiotensin II alone.", "ru": "Предварительное воздействие предсердного натрийуретического пептида в течение суток ослабляет вызванное ангиотензином II фосфорилирование ERK в человеческих клетках надпочечника H295R.", "observed": "Twenty-four-hour peptide exposure reduced the subsequent angiotensin-II ERK phosphorylation response.", "observedRu": "Суточное воздействие пептида уменьшило последующий ответ ERK на ангиотензин II.", "figure": "Supplementary Figure S3B", "paragraph": "p37", "quote": "a longer 24-hour pretreatment significantly attenuated", "id": "Hca11ba345120", "sourceId": "B42717871", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Whole-body Ghr ablation initiated at twelve months improves insulin sensitivity in male mice at twenty-three months relative to controls.", "ru": "Удаление Ghr во всём организме, начатое в 12 месяцев, повышает чувствительность к инсулину у самцов мышей в возрасте 23 месяцев относительно контроля.", "observed": "Male insulin sensitivity improved at nineteen and twenty-three months, P < 0.0001.", "observedRu": "Чувствительность к инсулину у самцов повысилась в 19 и 23 месяца, P < 0,0001.", "figure": "Figure 2h-j", "paragraph": "p11", "quote": "Insulin sensitivity was significantly improved only in male", "id": "H9512eff47edd", "sourceId": "B42698366", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Chronic diosmin supplementation increases plasma malondialdehyde in aged rats relative to vehicle-treated aged rats.", "ru": "Длительный приём диосмина повышает содержание малонового диальдегида в плазме старых крыс относительно старых крыс, получающих растворитель.", "observed": "Plasma malondialdehyde significantly decreased.", "observedRu": "Содержание малонового диальдегида в плазме достоверно снизилось.", "figure": "Figure 3A", "paragraph": "p26", "quote": "significantly decreased the MDA", "id": "H3525a80080db", "sourceId": "B42650473", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Twenty-eight days of HFI-419 treatment preserves glomerular filtration in twenty-seven- to twenty-eight-month-old wild-type mice relative to vehicle treatment.", "ru": "Лечение HFI-419 в течение 28 дней сохраняет клубочковую фильтрацию у обычных мышей в возрасте от 27 до 28 месяцев относительно введения растворителя.", "observed": "Treatment prevented the approximately 22% filtration decline seen in vehicle controls, P < 0.01.", "observedRu": "Лечение предотвратило снижение фильтрации примерно на 22%, наблюдавшееся в контроле с растворителем, P < 0,01.", "figure": "Figure 2A", "paragraph": "p25", "quote": "prevented the age-related decline in GFR", "id": "H1ca81581ce0f", "sourceId": "B42690146", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Esr1 knockdown increases Sirt1 gene expression in differentiated C2C12 myotubes relative to control siRNA.", "ru": "Подавление Esr1 увеличивает экспрессию Sirt1 в дифференцированных мышечных трубочках C2C12 относительно контрольной малой интерферирующей РНК.", "observed": "Esr1 knockdown reduced Sirt1 expression.", "observedRu": "Подавление Esr1 снизило экспрессию Sirt1.", "figure": "Figure 4C", "paragraph": "p15", "quote": "knockdown of Esr1 reduced Sirt1 gene expression", "id": "Hface15f9c0aa", "sourceId": "B42637079", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "XL20 at 50 mg/kg intraperitoneally three times weekly starting at forty-five days extends survival in male TDP43-A315T transgenic mice relative to vehicle.", "ru": "Внутрибрюшинное введение XL20 по 50 мг/кг три раза в неделю с 45-дневного возраста увеличивает выживаемость самцов трансгенных мышей TDP43-A315T относительно растворителя.", "observed": "Treated male mice exhibited increased lifespan.", "observedRu": "Продолжительность жизни получавших лечение самцов выросла.", "figure": "Figure 4e", "paragraph": "p13", "quote": "a notable increase in lifespan", "id": "He22abf94c32e", "sourceId": "B42399370", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "LSD1 overexpression accelerates gamma-H2AX clearance after 5 Gy irradiation in mouse 3T3 fibroblasts relative to vector controls.", "ru": "Усиление экспрессии LSD1 ускоряет исчезновение γH2AX после облучения мышиных фибробластов 3T3 дозой 5 Гр относительно контрольного вектора.", "observed": "LSD1 overexpression delayed gamma-H2AX resolution through 48 hours.", "observedRu": "Усиление экспрессии LSD1 задержало исчезновение γH2AX до 48 часов.", "figure": "Figure 4B", "paragraph": "p14", "quote": "delayed γH2AX resolution up to 48 hours", "id": "H27c93d908b66", "sourceId": "B42741942", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Osteocyte-specific Rankl deletion extends median lifespan of Zmpste24-null progeroid mice compared with Rankl-intact progeroid controls.", "ru": "Удаление Rankl в остеоцитах увеличивает медианную продолжительность жизни мышей с прогерией, вызванной удалением Zmpste24, по сравнению с такими же мышами с сохранённым Rankl.", "observed": "Pooled median lifespan rose from 230 to 276 days; p=0.0096.", "observedRu": "Медианная продолжительность жизни в объединённой группе выросла с 230 до 276 дней; P = 0,0096.", "figure": "Figure 4a", "paragraph": "p13", "quote": "a median lifespan of 276 days versus 230 days", "id": "H6512044a8ab4", "sourceId": "B42572248", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "L-carnitine reduces liver metastatic foci after intrasplenic injection of ALDH6A1-deficient AGS gastric cancer cells into nude mice relative to untreated deficient-cell controls.", "ru": "L-карнитин уменьшает число метастатических очагов в печени после введения в селезёнку бестимусных мышей клеток рака желудка AGS с удалённым ALDH6A1 относительно контроля с такими же клетками без лечения.", "observed": "L-carnitine reduced metastatic foci.", "observedRu": "L-карнитин уменьшил число метастатических очагов.", "figure": "Figure 8E,F", "paragraph": "p32", "quote": "markedly reduced metastatic foci", "id": "H08fabc33f46f", "sourceId": "B42418576", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Vascular-smooth-muscle-cell-specific Mapk14 deletion increases aortic collagen deposition in eighty-six-week-old hyperlipidemic mice relative to age- and sex-matched controls.", "ru": "Удаление Mapk14 в гладкомышечных клетках сосудов усиливает отложение коллагена в аорте 86-недельных мышей с гиперлипидемией относительно контроля того же возраста и пола.", "observed": "Collagen deposition decreased by Picrosirius Red quantification.", "observedRu": "Количественная оценка окрашивания пикросириусом красным показала уменьшение отложений коллагена.", "figure": "Figure 5C,D", "paragraph": "p15", "quote": "decreased collagen deposition in KO mice", "id": "H2a2948ff61da", "sourceId": "B42782728", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Myeloid-specific CK2-alpha deletion extends median lifespan in male mice compared with floxed controls.", "ru": "Удаление CK2α в миелоидных клетках увеличивает медианную продолжительность жизни самцов мышей относительно контрольных животных.", "observed": "Median lifespan fell from 733.5 to 502 days; 28 mice per group, p<0.001.", "observedRu": "Медианная продолжительность жизни снизилась с 733,5 до 502 дней; по 28 мышей в группе, P < 0,001.", "figure": "Figure 6b", "paragraph": "p18", "quote": "502 days (cKO) vs. 733.5 days (control)", "id": "He13f903f3124", "sourceId": "B42749730", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Psme4/PA200 deletion reduces urethane-induced lung tumor counts in middle-aged mice relative to wild-type controls.", "ru": "Удаление Psme4/PA200 снижает число вызванных уретаном опухолей лёгкого у мышей среднего возраста относительно обычных контрольных мышей.", "observed": "PA200 deletion significantly reduced tumor counts, particularly in middle-aged mice.", "observedRu": "Удаление PA200 снизило число опухолей; эффект был сильнее у мышей среднего возраста.", "figure": "Figure 6b,c", "paragraph": "p20", "quote": "PA200 deficiency significantly reduced tumor numbers", "id": "H2b4d50ec1df1", "sourceId": "B42884025", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "ORY-1001 at 0.04 mg/kg every other day for eight weeks reduces kidney p16 protein after 7 Gy irradiation in C57BL/6J mice relative to saline.", "ru": "Введение ORY-1001 по 0,04 мг/кг через день в течение восьми недель снижает содержание p16 в почках мышей линии C57BL/6J после облучения дозой 7 Гр по сравнению с введением физиологического раствора.", "observed": "LSD1 inhibition reduced radiation-associated p16 and p21 in kidney tissue.", "observedRu": "Блокирование LSD1 снизило вызванное облучением содержание p16 и p21 в почках.", "figure": "Figure 3C,D", "paragraph": "p10", "quote": "ORY-1001 treatment reduced both mRNA and protein levels", "id": "H3c13b7e2d082", "sourceId": "B42741942", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "TRPV4 knockout reduces skin mitochondrial reactive oxygen species after seven days of topical imiquimod in mice compared with imiquimod-treated wild-type controls.", "ru": "Удаление TRPV4 снижает содержание митохондриальных активных форм кислорода в коже мышей после семи дней нанесения имиквимода относительно обычных мышей с тем же воздействием.", "observed": "Knockout significantly attenuated the imiquimod-induced MitoSOX signal increase.", "observedRu": "Удаление гена уменьшило вызванный имиквимодом рост сигнала MitoSOX.", "figure": "Figure 1G,H", "paragraph": "p20", "quote": "TRPV4 deletion significantly attenuated the IMQ-induced ROS level increment", "id": "H168dc0d22104", "sourceId": "B42782838", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Skeletal-muscle-specific Pla2g6/iPLA2-beta deletion preserves extensor digitorum longus specific force after mouse muscle denervation compared with denervated wild-type controls.", "ru": "Удаление Pla2g6/iPLA2β в скелетных мышцах сохраняет удельную силу длинного разгибателя пальцев после денервации у мышей относительно обычных животных с денервацией.", "observed": "Denervated specific force was 20 versus 16 N/cm² after deletion and in wild-type controls.", "observedRu": "После денервации удельная сила составила 20 Н/см² при удалённом гене и 16 Н/см² в обычном контроле.", "figure": "Figure 1F", "paragraph": "p5", "quote": "20 N/cm2", "id": "Hb471544edd7b", "sourceId": "B42467794", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Four days of folate deprivation increases spontaneous interleukin-6 secretion by human HK-2 renal tubular cells compared with folate-replete culture.", "ru": "Четыре дня дефицита фолата усиливают спонтанную секрецию интерлейкина-6 человеческими клетками почечных канальцев HK-2 относительно культуры с достаточным фолатом.", "observed": "Folate deficiency increased interleukin-6 secretion without lipopolysaccharide stimulation.", "observedRu": "Дефицит фолата усилил секрецию интерлейкина-6 без стимуляции липополисахаридом.", "figure": "Figure 1A", "paragraph": "p11", "quote": "folate deficiency significantly increased IL-6 and MCP-1 secretion", "id": "H691ed522cf5f", "sourceId": "B42884089", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Constitutive skeletal-muscle-specific Crls1 deletion increases lean-mass gain after weaning in mice relative to control littermates.", "ru": "Постоянное удаление Crls1 в скелетных мышцах увеличивает прирост безжировой массы после отъёма мышат относительно контрольных животных того же помёта.", "observed": "Knockout mice failed to gain lean mass normally and developed muscle atrophy.", "observedRu": "Прирост безжировой массы у мышей с удалённым геном был снижен; развилась атрофия мышц.", "figure": "Figure 1g,h", "paragraph": "p9", "quote": "a failure to gain lean mass", "id": "H26edd2d7f68a", "sourceId": "B42811121", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "FNDC1 knockdown further increases proliferation of ZBED6-deficient primary porcine muscle satellite cells relative to control siRNA in ZBED6-deficient cells.", "ru": "Подавление FNDC1 дополнительно усиливает деление первичных сателлитных клеток мышц свиньи с подавленным ZBED6 по сравнению с контрольной малой интерферирующей РНК на том же фоне.", "observed": "FNDC1 knockdown attenuated the increased proliferation caused by ZBED6 depletion.", "observedRu": "Подавление FNDC1 ослабило усиление деления клеток, вызванное подавлением ZBED6.", "figure": "Figure 3A,B", "paragraph": "p29", "quote": "significantly attenuated the increased cell proliferation", "id": "H16065de616b9", "sourceId": "B42830286", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Weekly intraperitoneal PDK4-IN at 10 mg/kg for 16 weeks lowers serum ALT in 20-month-old male hepatocyte-specific GHR-knockout mice relative to vehicle.", "ru": "Еженедельное внутрибрюшинное введение PDK4-IN по 10 мг/кг в течение 16 недель снижает активность аланинаминотрансферазы в сыворотке 20-месячных самцов мышей с удалённым GHR в гепатоцитах.", "observed": "PDK4-IN reduced serum ALT relative to vehicle; six mice per group.", "observedRu": "PDK4-IN снизил активность аланинаминотрансферазы в сыворотке по сравнению с растворителем; в каждой группе было шесть мышей.", "figure": "Figure 7A,C", "paragraph": "p48", "quote": "serum ALT and AST levels were decreased", "id": "H2a93004b1bf8", "sourceId": "B42791620", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Ak050834 deletion further reduces migration of D-galactose-treated primary mouse aortic smooth muscle cells relative to D-galactose-treated wild-type cells.", "ru": "Удаление Ak050834 дополнительно снижает миграцию первичных гладкомышечных клеток аорты мыши при воздействии D-галактозы относительно обычных клеток с тем же воздействием.", "observed": "Deletion rescued migration, increasing migrated-cell counts and scratch closure.", "observedRu": "Удаление гена восстановило миграцию, увеличив число мигрировавших клеток и скорость закрытия царапины.", "figure": "Figure 5D-G", "paragraph": "p42", "quote": "significantly rescued the D‐gal‐induced impairment of migratory capacity", "id": "H4cabb5322f8a", "sourceId": "B42610635", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Twenty-eight days of HFI-419 treatment increases kidney hydroxyproline in twenty-eight-month-old mice relative to vehicle-treated aged mice.", "ru": "Лечение HFI-419 в течение 28 дней повышает содержание гидроксипролина в почках 28-месячных мышей относительно старых мышей, получающих растворитель.", "observed": "Kidney hydroxyproline fell approximately 1.7-fold, P < 0.01.", "observedRu": "Содержание гидроксипролина в почках снизилось примерно в 1,7 раза, P < 0,01.", "figure": "Figure 2F", "paragraph": "p25", "quote": "∼1.7-fold reduction in renal hydroxyproline content", "id": "Hd7d86420f325", "sourceId": "B42690146", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Vascular-smooth-muscle-cell-specific Sirt7 deletion reduces abdominal aortic aneurysm rupture in Apoe-null mice receiving four weeks of angiotensin II relative to littermate controls.", "ru": "Удаление Sirt7 в гладкомышечных клетках сосудов снижает частоту разрыва аневризмы брюшной аорты у мышей с удалённым Apoe после четырёх недель инфузии ангиотензина II относительно контроля из того же помёта.", "observed": "Sirt7 deletion increased aneurysm rupture and mortality.", "observedRu": "Удаление Sirt7 повысило частоту разрыва аневризмы и смертность.", "figure": "Figure 2h,i", "paragraph": "p27", "quote": "increased aortic diameters, AAA incidence, rupture rate, mortality", "id": "Hd792b655ff7a", "sourceId": "B42420530", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Growth hormone given every other day for three weeks lowers testicular gamma-H2AX phosphorylation in aged male mice relative to untreated aged controls.", "ru": "Введение гормона роста через день в течение трёх недель снижает фосфорилирование γH2AX в семенниках старых самцов мышей относительно старых животных без лечения.", "observed": "Growth hormone reduced testicular H2AX phosphorylation in aged males.", "observedRu": "Гормон роста снизил фосфорилирование H2AX в семенниках старых самцов.", "figure": "Figure 5G", "paragraph": "p26", "quote": "a significant reduction in H2AX phosphorylation levels", "id": "Hd34f6a91bf41", "sourceId": "B42801556", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "HBEGF overexpression in Prx1-lineage skeletal progenitors increases cartilage and bone area ten days after femoral fracture in sixteen-month-old mice relative to age-matched wild-type mice.", "ru": "Повышение экспрессии HBEGF в клетках-предшественниках скелета линии Prx1 увеличивает площадь хряща и кости через десять дней после перелома бедренной кости у 16-месячных мышей относительно обычных мышей того же возраста.", "observed": "Cartilage and bone area increased significantly at day ten.", "observedRu": "На десятый день площадь хряща и кости достоверно выросла.", "figure": "Figure 3A-D", "paragraph": "p11", "quote": "significantly increased cartilage and bone area at 10 dpf", "id": "Hae60cea8ffbf", "sourceId": "B42598518", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Four weeks of navitoclax treatment improves glucose tolerance in sixteen-week-old mice with pancreatic beta-cell-specific Fmo3 deletion relative to vehicle treatment.", "ru": "Четыре недели лечения навитоклаксом улучшают переносимость глюкозы у 16-недельных мышей с удалённым Fmo3 в бета-клетках поджелудочной железы относительно введения растворителя.", "observed": "Treatment improved glucose tolerance and glucose-stimulated insulin secretion.", "observedRu": "Улучшились переносимость глюкозы и вызванная глюкозой секреция инсулина.", "figure": "Supplementary Figure 9e,f", "paragraph": "p26", "quote": "potentiated GSIS and improved glucose tolerance", "id": "Hed8ca67e265e", "sourceId": "B42649194", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Deleting membrane-bound COMT improves PC12 cell viability after twenty-four hours of 200 micromolar hydrogen peroxide compared with wild-type cells.", "ru": "Удаление мембранной COMT повышает жизнеспособность клеток PC12 после суток воздействия 200 мкМ пероксида водорода относительно обычных клеток.", "observed": "COMT-deficient cells had significantly lower viability after 200 micromolar peroxide.", "observedRu": "После 200 мкМ пероксида жизнеспособность клеток без COMT была ниже.", "figure": "Figure 1B", "paragraph": "p9", "quote": "the viability of MB-COMT −/− cells was significantly lower", "id": "Hcc115f2aa2b3", "sourceId": "B42748150", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Dietary coenzyme Q10 increases collagen-induced platelet aggregation in twenty-two-month-old mice relative to age-matched unsupplemented controls.", "ru": "Коэнзим Q10 в рационе усиливает вызванную коллагеном агрегацию тромбоцитов у двадцатидвухмесячных мышей относительно животных того же возраста без добавки.", "observed": "Coenzyme Q10 suppressed collagen-induced aggregation at twenty-two months; p<0.05.", "observedRu": "Коэнзим Q10 подавил вызванную коллагеном агрегацию в двадцатидвухмесячном возрасте; P < 0,05.", "figure": "Figure 10A", "paragraph": "p23", "quote": "significantly suppressed platelet aggregation", "id": "Hfeee2fca0479", "sourceId": "B42808563", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Nanoparticle-delivered Sema3g siRNA reduces hepatic hydroxyproline during carbon-tetrachloride-induced fibrosis in male endothelial-Fbxw7-knockout mice relative to scramble siRNA.", "ru": "Малая интерферирующая РНК к Sema3g в наночастицах снижает содержание гидроксипролина в печени самцов мышей с удалённым Fbxw7 в эндотелии при фиброзе, вызванном четырёххлористым углеродом, относительно контрольной РНК.", "observed": "Hydroxyproline and histological collagen measurements showed decreased fibrosis.", "observedRu": "Содержание гидроксипролина и гистологическая оценка коллагена показали уменьшение фиброза.", "figure": "Figure 6G-I", "paragraph": "p16", "quote": "decreased fibrosis measured by hydroxyproline content", "id": "He6acd9cc7f13", "sourceId": "B42823407", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Vascular-smooth-muscle-cell-specific Mapk14 deletion reduces aortic-arch calcium deposition in eighty-six-week-old hyperlipidemic mice on normal chow relative to age- and sex-matched controls.", "ru": "Удаление Mapk14 в гладкомышечных клетках сосудов уменьшает отложение кальция в дуге аорты 86-недельных мышей с гиперлипидемией на обычном корме относительно контроля того же возраста и пола.", "observed": "Von Kossa and Alizarin Red measurements showed less mineral deposition.", "observedRu": "Окрашивание по фон Косса и ализариновым красным показало уменьшение минеральных отложений.", "figure": "Figure 4B-E", "paragraph": "p14", "quote": "reduced calcified area in both male and female mice", "id": "H205c5e7920f5", "sourceId": "B42782728", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "GSR inhibition reduces aggregation of lipoylated DLAT during elesclomol-copper treatment in cancer cells relative to treatment without GSR inhibition.", "ru": "Ингибирование GSR уменьшает агрегацию липоилированного DLAT при воздействии комплекса элескломола с медью на раковые клетки относительно такого же воздействия без ингибирования GSR.", "observed": "GSR inhibition markedly promoted DLAT aggregation.", "observedRu": "Ингибирование GSR заметно усилило агрегацию DLAT.", "figure": "Figure 2F-I", "paragraph": "p83", "quote": "markedly promotes aggregation of the lipoylated protein DLAT", "id": "H1bfb037dac8f", "sourceId": "B42681644", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Twenty-four hours of alpha-synuclein treatment increases colocalization of lipid droplets with lysosomes in macrophages relative to untreated macrophages.", "ru": "Суточное воздействие альфа-синуклеина усиливает пространственное совпадение липидных капель и лизосом в макрофагах относительно клеток без воздействия.", "observed": "LysoTracker and lipid-droplet colocalization markedly decreased.", "observedRu": "Пространственное совпадение сигналов LysoTracker и липидных капель заметно уменьшилось.", "figure": "Figure 4c,e", "paragraph": "p21", "quote": "was markedly reduced", "id": "H3fc3c2c34cee", "sourceId": "B42806619", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Sost deletion reduces tibial cortical vascular porosity in seventy-eight-week-old mice compared with littermate controls.", "ru": "Удаление Sost уменьшает сосудистую пористость кортикального слоя большеберцовой кости у мышей в возрасте семидесяти восьми недель относительно контрольных животных того же помёта.", "observed": "Vascular porosity was 332% greater in elderly knockout mice.", "observedRu": "Сосудистая пористость у старых мышей с удалённым геном была выше на 332%.", "figure": "Figure 4A; Table 4", "paragraph": "p45", "quote": "vascular porosity (332%)", "id": "H6b18aea23456", "sourceId": "B42502704", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Oxaliplatin combined with anti-PD-1 and anti-ACBP/DBI antibodies prolongs survival of female C57BL/6J mice bearing MCA205 fibrosarcomas with Lmna-sufficient T cells versus vehicle.", "ru": "Сочетание оксалиплатина с антителами к PD-1 и ACBP/DBI увеличивает выживаемость самок мышей C57BL/6J с фибросаркомами MCA205 и сохранённым Lmna в T-клетках по сравнению с введением растворителя.", "observed": "Six of nine treated females survived long-term; vehicle animals died by day 25.", "observedRu": "Шесть из девяти леченных самок выжили при длительном наблюдении; все контрольные животные погибли к 25-му дню.", "figure": "Figure 1B,C", "paragraph": "p11", "quote": "permitting protracted survival of 6 out of 9 mice", "id": "H4e43005c4648", "sourceId": "B42774966", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Myeloid-specific Slc1a5 deletion increases the liver-to-body-weight ratio forty-eight hours after two-thirds hepatectomy in mice relative to littermate controls.", "ru": "Удаление Slc1a5 в миелоидных клетках повышает отношение массы печени к массе тела через 48 часов после удаления двух третей печени у мышей относительно контрольных мышей из того же помёта.", "observed": "Deficiency impaired liver regrowth and reduced the liver-to-body-weight ratio.", "observedRu": "Удаление Slc1a5 замедлило восстановление печени и снизило отношение её массы к массе тела.", "figure": "Figure 2a,b", "paragraph": "p9", "quote": "macrophage Slc1a5 deficiency impaired liver regeneration", "id": "H8925efa06267", "sourceId": "B42678502", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Enzymatically hydrolyzed eggshell membrane at 4 mg/mL decreases Akt Ser473 phosphorylation in neonatal human epidermal keratinocytes relative to untreated controls.", "ru": "Ферментативный гидролизат подскорлупной оболочки в концентрации 4 мг/мл снижает фосфорилирование Akt по Ser473 в эпидермальных кератиноцитах новорождённого человека относительно контроля.", "observed": "Akt Ser473 phosphorylation increased at 4 mg/mL despite the earlier microarray prediction.", "observedRu": "При 4 мг/мл фосфорилирование Akt по Ser473 усилилось вопреки прежнему прогнозу по микроматрице.", "figure": "Figure 3C", "paragraph": "p27", "quote": "Akt phosphorylation at Ser473 significantly increased", "id": "H93c55cfc0f98", "sourceId": "B42644214", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "AZ3451 pretreatment increases PAR2-agonist-evoked intracellular calcium in human SW982 synoviocytes relative to agonist alone.", "ru": "Предварительное воздействие AZ3451 усиливает вызванный агонистом PAR2 рост внутриклеточного кальция в человеческих синовиоцитах SW982 относительно одного агониста.", "observed": "AZ3451 blocked the agonist-evoked calcium increase.", "observedRu": "AZ3451 заблокировал вызванный агонистом рост внутриклеточного кальция.", "figure": "Figure 5A,B", "paragraph": "p26", "quote": "significantly blocked by pre-incubation with AZ3451", "id": "H685f8b5e8567", "sourceId": "B42726576", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Myeloid-specific Rora deletion decreases the proportion of leaky laser-induced choroidal neovascular lesions in eight-month-old mice relative to floxed controls.", "ru": "Удаление Rora в миелоидных клетках уменьшает долю очагов хориоидальной неоваскуляризации с сосудистой утечкой после лазерного воздействия у восьмимесячных мышей относительно контрольных животных.", "observed": "Leaky lesions increased from 41% in controls to 84% in the knockout group.", "observedRu": "Доля очагов с утечкой выросла с 41% в контроле до 84% после удаления гена.", "figure": "Figure 4F", "paragraph": "p16", "quote": "84% of Rorafl/fl;LysMCre CNV lesions were graded as leaky", "id": "H0d7baa86124c", "sourceId": "B42788989", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Oxamate inhibition of lactate dehydrogenase increases mitochondrial reactive oxygen species in folate-deficient HK-2 renal tubular cells compared with untreated deficient cells.", "ru": "Блокирование лактатдегидрогеназы оксаматом повышает содержание митохондриальных активных форм кислорода в клетках HK-2 при дефиците фолата относительно клеток с тем же дефицитом без оксамата.", "observed": "Inhibiting endogenous lactate production reduced mitochondrial oxidative stress.", "observedRu": "Подавление образования собственного лактата снизило митохондриальный окислительный стресс.", "figure": "Figure 4C", "paragraph": "p20", "quote": "reduced both intracellular and mitochondrial ROS levels", "id": "H2b4e72ef481d", "sourceId": "B42884089", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Glucagon-receptor-blocking antibody lowers the glucose-tolerance-test area under the curve in aged mice relative to control antibody.", "ru": "Антитело, блокирующее рецептор глюкагона, уменьшает площадь под кривой теста переносимости глюкозы у старых мышей относительно контрольного антитела.", "observed": "Glucose concentrations and the area under the curve decreased.", "observedRu": "Концентрация глюкозы и площадь под кривой снизились.", "figure": "Figure 3C,D", "paragraph": "p45", "quote": "a reduced area under the curve", "id": "Heff387c84521", "sourceId": "B42458466", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Daily taurine gavage lowers the hepatic phosphorylated-AMPK to total-AMPK ratio in hypothyroid rats relative to water gavage.", "ru": "Ежедневное введение таурина через зонд снижает отношение фосфорилированной AMPK к общему содержанию AMPK в печени крыс с гипотиреозом относительно введения воды.", "observed": "The phosphorylated-AMPK to total-AMPK ratio increased.", "observedRu": "Отношение фосфорилированной AMPK к общему содержанию AMPK выросло.", "figure": "Figure 6A", "paragraph": "p29", "quote": "higher levels of phosphorylated AMPK", "id": "Hc6cc3302a45a", "sourceId": "B42485573", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Endothelial Fbxw7 deletion reduces hepatic collagen deposition after carbon tetrachloride exposure in male mice relative to control mice.", "ru": "Удаление Fbxw7 в эндотелии уменьшает отложение коллагена в печени самцов мышей после воздействия четырёххлористого углерода относительно контрольных мышей.", "observed": "Knockout exacerbated fibrosis by hydroxyproline, Sirius Red and COL1A1 measurements.", "observedRu": "Удаление гена усилило фиброз по содержанию гидроксипролина, окрашиванию Sirius Red и сигналу COL1A1.", "figure": "Figure 1E-G", "paragraph": "p6", "quote": "enhanced fibrosis measured by hydroxyproline content", "id": "H282a9ffdd7fd", "sourceId": "B42823407", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Anti-RANKL antibody at 5 mg/kg twice weekly reduces trabecular bone mineral density in Zmpste24-null progeroid mice relative to isotype antibody.", "ru": "Антитела к RANKL по 5 мг/кг дважды в неделю снижают минеральную плотность трабекулярной кости у мышей с прогерией, вызванной удалением Zmpste24, по сравнению с изотипическим контролем.", "observed": "Anti-RANKL increased trabecular mineral density and preserved bone structure.", "observedRu": "Антитела к RANKL повысили минеральную плотность трабекулярной кости и сохранили её структуру.", "figure": "Figure 5a-d", "paragraph": "p15", "quote": "BMD, BV/TV and Tb.Th—were significantly increased", "id": "H2a4cf9bb2c83", "sourceId": "B42572248", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "Ak050834 deletion reduces vascular beta-galactosidase staining in naturally aged mice relative to wild-type aged mice.", "ru": "Удаление Ak050834 уменьшает окрашивание сосудов на бета-галактозидазу у естественно состарившихся мышей относительно обычных старых мышей.", "observed": "Vascular beta-galactosidase staining decreased markedly.", "observedRu": "Окрашивание сосудов на бета-галактозидазу заметно уменьшилось.", "figure": "Figure 4A,B", "paragraph": "p39", "quote": "markedly reduced the expression of β‐galactosidase", "id": "H1501b5ea0040", "sourceId": "B42610635", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "pyr-1 RNA interference extends Caenorhabditis elegans lifespan under normal culture conditions relative to empty-vector RNA interference.", "ru": "Подавление pyr-1 с помощью РНК-интерференции увеличивает продолжительность жизни Caenorhabditis elegans при обычном содержании относительно контрольного пустого вектора.", "observed": "pyr-1 disruption shortened lifespan and citrulline rescued the reduction.", "observedRu": "Нарушение pyr-1 сократило продолжительность жизни; добавление цитруллина устранило это сокращение.", "figure": "Figure 2i,j", "paragraph": "p11", "quote": "led to shorter lifespan than the control", "id": "Hf7ad0950ca22", "sourceId": "B42448700", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "The GSK3-beta inhibitor SB216763 reduces lung fibrosis in mice with conditional beta-PIX deletion in alveolar type-II cells relative to vehicle treatment.", "ru": "Ингибитор GSK3-бета SB216763 уменьшает фиброз лёгких у мышей с условным удалением бета-PIX в альвеолярных клетках второго типа относительно введения растворителя.", "observed": "Masson's trichrome staining showed reduced fibrosis.", "observedRu": "Окрашивание трихромом Массона показало уменьшение фиброза.", "figure": "Figure 5b", "paragraph": "p24", "quote": "SB reduced fibrosis in the KO mice", "id": "Hfbd997710a91", "sourceId": "B42716949", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Dietary citrulline at 10 mM extends Caenorhabditis elegans median survival under normal culture conditions relative to unsupplemented controls.", "ru": "Цитруллин в концентрации 10 мМ в питании увеличивает медианную выживаемость Caenorhabditis elegans при обычном содержании относительно контроля без добавки.", "observed": "Median survival increased from 14.5 to 17.0 days.", "observedRu": "Медианная выживаемость выросла с 14,5 до 17,0 дня.", "figure": "Figure 1j,k", "paragraph": "p8", "quote": "from 14.5 ± 0.5 to 17.0 ± 0.8 days", "id": "H54e4307dd731", "sourceId": "B42448700", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Endothelial-specific Piezo1 deletion reduces hippocampal sodium-fluorescein leakage after anesthesia and surgery in mice relative to Piezo1-intact controls.", "ru": "Удаление Piezo1 в эндотелии уменьшает утечку флуоресцеина натрия в гиппокамп после наркоза и операции у мышей относительно контроля с сохранённым Piezo1.", "observed": "Sodium-fluorescein leakage significantly decreased.", "observedRu": "Утечка флуоресцеина натрия достоверно уменьшилась.", "figure": "Figure 6B-D", "paragraph": "p15", "quote": "significantly reduced NaFL leakage", "id": "Hcac20bec2aa2", "sourceId": "B42591729", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": false, "en": "Intra-articular AAV-driven constitutive ERK5 activation lowers knee cartilage OARSI scores eight weeks after meniscal destabilization in adult mice relative to control AAV.", "ru": "Постоянная активация ERK5 с помощью внутрисуставного AAV снижает балл повреждения коленного хряща OARSI через восемь недель после дестабилизации мениска относительно контрольного AAV.", "observed": "Activated ERK5 produced higher OARSI damage grades; six mice per group.", "observedRu": "Активация ERK5 повысила балл повреждения хряща; по шесть мышей в группе.", "figure": "Figure 3d", "paragraph": "p10", "quote": "higher OARSI grades relative to the AAV-NC group", "id": "H076a42491f62", "sourceId": "B42686685", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Hepatocyte-specific Nos3/eNOS deletion reduces serum ALT activity after two weeks of carbon-tetrachloride challenge in mice compared with floxed controls.", "ru": "Удаление Nos3/eNOS в гепатоцитах снижает активность аланинаминотрансферазы в сыворотке мышей после двух недель воздействия четырёххлористого углерода относительно контроля.", "observed": "Hepatocyte eNOS deficiency increased liver-injury enzyme activities after carbon tetrachloride.", "observedRu": "Дефицит eNOS в гепатоцитах повысил активность ферментов повреждения печени после четырёххлористого углерода.", "figure": "Figure 3C,D", "paragraph": "p8", "quote": "aggravated liver dysfunction evident by serum ALT and AST activity assay", "id": "H87388412c2a6", "sourceId": "B42801580", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": false, "en": "Muscle-specific Pla2g6/iPLA2-beta deletion further reduces depolarization-evoked force in denervated mouse fast-twitch fibers compared with denervated wild-type fibers.", "ru": "Удаление Pla2g6/iPLA2β в мышцах дополнительно снижает силу сокращения при деполяризации денервированных быстрых мышечных волокон относительно денервированных волокон обычных мышей.", "observed": "Deletion preserved depolarization response near 30% of maximum versus below 5% in denervated wild-type fibers.", "observedRu": "После удаления гена ответ на деполяризацию сохранялся около 30% максимума против менее 5% в обычных денервированных волокнах.", "figure": "Figure 5A,B", "paragraph": "p13", "quote": "deletion of iPLA2β significantly preserved excitability", "id": "Hbe6b696a434f", "sourceId": "B42467794", "adjudication": "measured_direction_contradicts_claim" }, { "confirmed": true, "en": "The PPAR-gamma antagonist T0070907 reduces laser-induced choroidal neovascular lesion size in two-to-three-month-old myeloid-specific Rora-knockout mice compared with vehicle.", "ru": "Антагонист PPARγ T0070907 уменьшает вызванные лазером очаги хориоидальной неоваскуляризации у двух-трёхмесячных мышей с удалённым Rora в миелоидных клетках относительно растворителя.", "observed": "PPAR-gamma inhibition significantly reduced neovascular lesion size in the knockout mice.", "observedRu": "Блокирование PPARγ уменьшило очаги неоваскуляризации у мышей с удалённым геном.", "figure": "Figure 9A", "paragraph": "p33", "quote": "significantly attenuated CNV lesion size", "id": "H7f9a0c89b5f6", "sourceId": "B42788989", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Hepatocyte-specific Sirt6 deletion increases hepatic Sult1e1 gene expression in aged female mice relative to floxed controls.", "ru": "Удаление Sirt6 в гепатоцитах повышает экспрессию Sult1e1 в печени старых самок мышей относительно контроля с сохранённым геном.", "observed": "Sult1e1 increased 7.54-fold, P = 0.035.", "observedRu": "Экспрессия Sult1e1 выросла в 7,54 раза, P = 0,035.", "figure": "Figure 6D", "paragraph": "p19", "quote": "Sult1e1 (+7.54-fold, p = 0.035)", "id": "H0e9581097799", "sourceId": "B42589691", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "SDF-1 at 10 micrograms/kg intraperitoneally for fourteen days increases pups per litter in aged female mice relative to saline-treated aged controls.", "ru": "Внутрибрюшинное введение SDF-1 по 10 мкг/кг в течение четырнадцати дней увеличивает число детёнышей в помёте у старых самок мышей относительно физиологического раствора.", "observed": "Pups per litter increased from 4.5 to 7.7; p<0.001.", "observedRu": "Среднее число детёнышей в помёте выросло с 4,5 до 7,7; P < 0,001.", "figure": "Figure 3G", "paragraph": "p10", "quote": "7.7±0.7 vs. 4.5±0.4, p < 0.001", "id": "Hb3e6742eec1d", "sourceId": "B42544868", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Skeletal-muscle-specific Crls1 deletion decreases the proportion of type IIb fibers in mouse extensor digitorum longus compared with control littermates.", "ru": "Удаление Crls1 в скелетных мышцах снижает долю волокон типа IIb в длинном разгибателе пальцев мышей относительно контрольных животных того же помёта.", "observed": "Crls1 deletion shifted EDL away from type IIb toward oxidative IIa and IIx fibers.", "observedRu": "После удаления Crls1 доля волокон IIb снизилась, а доли окислительных волокон IIa и IIx выросли.", "figure": "Figure 2d,e", "paragraph": "p19", "quote": "a significant decrease in the most glycolytic type IIb fibers", "id": "Hb1e07c55f832", "sourceId": "B42811121", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Re-expression of wild-type human GSR restores resistance to RSL3-induced ferroptosis in Gsr-knockout mouse 4T1 breast cancer cells relative to empty-vector knockout cells.", "ru": "Восстановление экспрессии человеческого GSR дикого типа восстанавливает устойчивость к ферроптозу, вызванному RSL3, в клетках рака молочной железы мыши 4T1 с удалённым Gsr по сравнению с такими же клетками с пустым вектором.", "observed": "Wild-type GSR fully restored resistance; a catalytically inactive mutant did not.", "observedRu": "GSR дикого типа полностью восстановил устойчивость; каталитически неактивный вариант этого не сделал.", "figure": "Figure 1H", "paragraph": "p73", "quote": "fully restored ferroptosis resistance", "id": "H583619d01105", "sourceId": "B42681644", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Dietary pterostilbene at 100 mg per kg of diet reduces weight gain during thirteen weeks of high-fat feeding in male mice relative to high-fat diet alone.", "ru": "Птеростильбен в дозе 100 мг на килограмм корма уменьшает прибавку массы у самцов мышей за 13 недель питания с высоким содержанием жира относительно такого же питания без добавки.", "observed": "Pterostilbene reduced high-fat-diet weight gain at 100 to 200 mg/kg diet.", "observedRu": "Птеростильбен уменьшил прибавку массы при 100-200 мг на килограмм корма.", "figure": "Figure 2B", "paragraph": "p9", "quote": "PTS exerted the effect at 100 to 200 mg/kg", "id": "H7b9b93427c7e", "sourceId": "B42637079", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Nicotinamide mononucleotide supplementation reduces abdominal aortic aneurysm incidence in angiotensin-II-infused Apoe-null mice relative to saline.", "ru": "Добавление никотинамидмононуклеотида снижает частоту аневризмы брюшной аорты у мышей с удалённым Apoe при инфузии ангиотензина II относительно физиологического раствора.", "observed": "Supplementation reduced aneurysm incidence, aortic dilation and mortality.", "observedRu": "Снизились частота аневризмы, расширение аорты и смертность.", "figure": "Figure 7b-f", "paragraph": "p45", "quote": "markedly reduced aortic dilation, AAA incidence, mortality", "id": "Hc2e66a4b720a", "sourceId": "B42420530", "adjudication": "reported_experiment_confirms_claim" }, { "confirmed": true, "en": "Chronic diosmin supplementation improves acetylcholine-induced vascular relaxation in aged rats relative to vehicle-treated aged rats.", "ru": "Длительный приём диосмина улучшает вызванное ацетилхолином расслабление сосудов старых крыс относительно старых крыс, получающих растворитель.", "observed": "Diosmin partially restored vascular relaxation to acetylcholine.", "observedRu": "Диосмин частично восстановил расслабление сосудов в ответ на ацетилхолин.", "figure": "Figure 1C,D", "paragraph": "p22", "quote": "induced a partial restoration of vascular relaxation", "id": "H4dc9b9da3a06", "sourceId": "B42650473", "adjudication": "reported_experiment_confirms_claim" } ], "editorialAmendment": { "at": "2026-10-22T23:27:44.281Z", "parentCohortSha256": "5ea9876c85431d3a046cd3bffcf87d6a84efa2e76250472d747f48822835eee8", "parentProtocolSha256": "deddc351c05faa4865ce20b3494c0e6f2a8a6cb649f79bc426ea4d208bf71503", "reason": "Russian editorial review before any forecast call; English claims, source labels, evidence, identities, order and random coin bytes/decisions preserved unchanged", "changedRussianClaimIds": [ "Hf84dc04d9967", "Hca5687df1d17", "H00754d90403e", "H591cc6bdd061", "H699141a0e533", "H2d91f2d3ca48", "Hbb8d36395a4f", "Hdc04751acc25", "Hc51c63819170", "H2bf61d6a2dae", "H69d1974ef6f3", "H6512044a8ab4", "He13f903f3124", "H3c13b7e2d082", "H16065de616b9", "H2a93004b1bf8", "Hfeee2fca0479", "H4e43005c4648", "H2a4cf9bb2c83", "Hb3e6742eec1d", "H583619d01105" ] } }