{"data":[{"id":"f34e1b2c-4292-4d6d-a60d-644e30f6176d","public_id":"D3DuGnO5","slug":"strategy-by-difficulty","title":"What do we do, depending on how difficult we believe ageing is?","question_text":"How should our strategy change depending on how complex we believe ageing to be?","plain_explanation":"Your worldview determines your strategy. If the drugs are already at the pharmacy, the work is clinical trials. If ageing cannot be slowed at all, the work is replacing what wears out. Between those two ends lie ten other positions, and each one dictates a different programme.","why_it_matters":"Every plan in longevity is a bet on where ageing sits on this line. Naming the level makes the bet visible.","what_we_know":null,"what_remains_uncertain":null,"next_action":"Read the twelve levels, from maximum optimism to maximum pessimism.","origin":"curator_authored","gap_types":[],"home_role":"featured","featured_rank":1,"publication_status":"published","answer_url":"/presentations/fight-death-en.html","answer_label":"The Spectrum of the Fight Against Death","answer_summary":null,"published_at":"2026-09-21","goal_id":"29a211a9-30e8-461d-8f1f-684453411c5f","goal_slug":"how-we-fight-death","goal_title":"How we fight death","published_hypotheses":0,"runs":0,"goal":{"id":"29a211a9-30e8-461d-8f1f-684453411c5f","public_id":"5JYtT0Zy","slug":"how-we-fight-death","title":"How we fight death","question_text":"What decides what we build, what we track, and what we publish?","summary":"Five questions. Choose them badly and the years and the money go into finding that out. Everything the engine writes -- rival explanations, the experiments that would decide between them -- sits under one of these.","body":null,"ordinal":0,"publication_status":"published"},"public_url":"https://eternalsearch.net/questions/strategy-by-difficulty","api_url":"https://eternalsearch.net/api/v1/content/questions/strategy-by-difficulty"},{"id":"e4a692a2-02a4-44f8-9e18-71853846d6c1","public_id":"AFgveRv2","slug":"which-hypotheses-first","title":"Which hypotheses do we test first, and who decides?","question_text":"How do we choose which hypotheses to test first? And how is that decided?","plain_explanation":"The engine does not pick a favourite. For every place where knowledge runs out it writes the whole field of rival explanations, binds each pair to the one observation that would separate them, and ranks the experiments rather than the ideas. The stem-cell niche below is the worked example: five rivals, one contested signal, one experiment that would knock some of them out.","why_it_matters":"A hypothesis tested first buys years. A hypothesis defended first costs them.","what_we_know":"Two S-nodes predict opposite TGF-β1 outcomes from the same SPM intervention in human macrophages.","what_remains_uncertain":"No human niche macrophage data on IRF4-TGF-β1 co-binding status during SPM-driven polarization; intervention direction is indeterminate.\n\nWhat is needed: Macrophage polarization state that clears senescent debris without TGF-β1-driven fibroblast activation.","next_action":"Compare the five rivals and read the observation that would separate them.","origin":"curator_authored","gap_types":["CLASH"],"home_role":"story","featured_rank":null,"publication_status":"published","answer_url":null,"answer_label":null,"answer_summary":null,"published_at":"2026-09-21","goal_id":"29a211a9-30e8-461d-8f1f-684453411c5f","goal_slug":"how-we-fight-death","goal_title":"How we fight death","published_hypotheses":5,"runs":1,"goal":{"id":"29a211a9-30e8-461d-8f1f-684453411c5f","public_id":"5JYtT0Zy","slug":"how-we-fight-death","title":"How we fight death","question_text":"What decides what we build, what we track, and what we publish?","summary":"Five questions. Choose them badly and the years and the money go into finding that out. Everything the engine writes -- rival explanations, the experiments that would decide between them -- sits under one of these.","body":null,"ordinal":0,"publication_status":"published"},"public_url":"https://eternalsearch.net/questions/which-hypotheses-first","api_url":"https://eternalsearch.net/api/v1/content/questions/which-hypotheses-first"},{"id":"d8101262-ca92-422d-a8dd-a6f592af84c7","public_id":"7qIRV5eF","slug":"where-are-the-bottlenecks","title":"Where exactly are the bottlenecks?","question_text":"Where exactly are the bottlenecks? In science, money, culture, politics, or language? And how can we overcome them?","plain_explanation":"A bottleneck is the point where more effort stops producing more progress. Some are experiments. Some are people, money, regulation or the words a field uses for itself. Locating them is the fourth step of making sense of a field, after gathering everything, establishing cause and effect, and finding the hidden variables.","why_it_matters":"Effort spent anywhere but at a bottleneck is motion that feels useful and changes nothing.","what_we_know":null,"what_remains_uncertain":null,"next_action":"Follow the levels of the spectrum where the bottleneck is named: delivery, methods, resources.","origin":"curator_authored","gap_types":[],"home_role":"featured","featured_rank":2,"publication_status":"published","answer_url":null,"answer_label":null,"answer_summary":null,"published_at":"2026-09-21","goal_id":"29a211a9-30e8-461d-8f1f-684453411c5f","goal_slug":"how-we-fight-death","goal_title":"How we fight death","published_hypotheses":0,"runs":0,"goal":{"id":"29a211a9-30e8-461d-8f1f-684453411c5f","public_id":"5JYtT0Zy","slug":"how-we-fight-death","title":"How we fight death","question_text":"What decides what we build, what we track, and what we publish?","summary":"Five questions. Choose them badly and the years and the money go into finding that out. Everything the engine writes -- rival explanations, the experiments that would decide between them -- sits under one of these.","body":null,"ordinal":0,"publication_status":"published"},"public_url":"https://eternalsearch.net/questions/where-are-the-bottlenecks","api_url":"https://eternalsearch.net/api/v1/content/questions/where-are-the-bottlenecks"},{"id":"c17edb45-eb97-4021-b779-f5ab871e6790","public_id":"qh53LBxu","slug":"a-culture-of-personal-longevity","title":"How does a culture come to care about one specific life?","question_text":"How can we create a cultural pattern that encourages interest in extending the life of a specific person?","plain_explanation":"Fields advance on language, images, arguments and stories, not on databases alone. The question is what makes the extension of a particular life -- yours, one person you can name -- culturally serious rather than abstract.","why_it_matters":"Without it, the goal stays a statistic and the money follows other statistics.","what_we_know":null,"what_remains_uncertain":null,"next_action":"Read the essays and posters: they are the platform’s answer in progress.","origin":"curator_authored","gap_types":[],"home_role":"featured","featured_rank":3,"publication_status":"published","answer_url":null,"answer_label":null,"answer_summary":null,"published_at":"2026-09-21","goal_id":"29a211a9-30e8-461d-8f1f-684453411c5f","goal_slug":"how-we-fight-death","goal_title":"How we fight death","published_hypotheses":0,"runs":0,"goal":{"id":"29a211a9-30e8-461d-8f1f-684453411c5f","public_id":"5JYtT0Zy","slug":"how-we-fight-death","title":"How we fight death","question_text":"What decides what we build, what we track, and what we publish?","summary":"Five questions. Choose them badly and the years and the money go into finding that out. Everything the engine writes -- rival explanations, the experiments that would decide between them -- sits under one of these.","body":null,"ordinal":0,"publication_status":"published"},"public_url":"https://eternalsearch.net/questions/a-culture-of-personal-longevity","api_url":"https://eternalsearch.net/api/v1/content/questions/a-culture-of-personal-longevity"},{"id":"fd5882c1-3a31-4424-8bb5-0efa8c417125","public_id":"S01hX97a","slug":"which-arena","title":"In which arena is the fight against death actually fought?","question_text":"In which arena does the fight against death primarily take place?","plain_explanation":"The laboratory, the clinic, the capital markets, the regulator, the culture, or the individual. The spectrum’s outer levels -- resources, foundations, autonomy, hope for the future, catastrophe -- are each an answer to this question.","why_it_matters":"The arena decides who the actors are and what counts as a win.","what_we_know":null,"what_remains_uncertain":null,"next_action":"Read levels eight to twelve of the spectrum.","origin":"curator_authored","gap_types":[],"home_role":"none","featured_rank":null,"publication_status":"published","answer_url":null,"answer_label":null,"answer_summary":null,"published_at":"2026-09-21","goal_id":"29a211a9-30e8-461d-8f1f-684453411c5f","goal_slug":"how-we-fight-death","goal_title":"How we fight death","published_hypotheses":0,"runs":0,"goal":{"id":"29a211a9-30e8-461d-8f1f-684453411c5f","public_id":"5JYtT0Zy","slug":"how-we-fight-death","title":"How we fight death","question_text":"What decides what we build, what we track, and what we publish?","summary":"Five questions. Choose them badly and the years and the money go into finding that out. Everything the engine writes -- rival explanations, the experiments that would decide between them -- sits under one of these.","body":null,"ordinal":0,"publication_status":"published"},"public_url":"https://eternalsearch.net/questions/which-arena","api_url":"https://eternalsearch.net/api/v1/content/questions/which-arena"}],"pagination":{"limit":50,"offset":0,"total":5,"has_more":false},"access_level":"public","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/","attribution":"Eternal Search (eternalsearch.net), powered by Open Longevity","scope":"Applies to data produced by Eternal Search (scores, rationale, extracted structures, summaries, graph). Third-party texts keep their own rights; see text_policy on each record."},"generated_at":"2026-11-15T09:22:51.223Z","family":"questions","index_url":"https://eternalsearch.net/questions"}